ID   A4YXG1_BRASO            Unreviewed;       431 AA.
AC   A4YXG1;
DT   29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=O-acetylhomoserine/O-acetylserine sulfhydrylase {ECO:0000313|EMBL:CAL78587.1};
DE            EC=2.5.1.49 {ECO:0000313|EMBL:CAL78587.1};
GN   Name=metC {ECO:0000313|EMBL:CAL78587.1};
GN   OrderedLocusNames=BRADO4873 {ECO:0000313|EMBL:CAL78587.1};
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Nitrobacteraceae; Bradyrhizobium.
OX   NCBI_TaxID=114615 {ECO:0000313|EMBL:CAL78587.1, ECO:0000313|Proteomes:UP000001994};
RN   [1] {ECO:0000313|EMBL:CAL78587.1, ECO:0000313|Proteomes:UP000001994}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278 {ECO:0000313|Proteomes:UP000001994};
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; CU234118; CAL78587.1; -; Genomic_DNA.
DR   RefSeq; WP_011927686.1; NC_009445.1.
DR   AlphaFoldDB; A4YXG1; -.
DR   STRING; 114615.BRADO4873; -.
DR   KEGG; bra:BRADO4873; -.
DR   eggNOG; COG2873; Bacteria.
DR   HOGENOM; CLU_018986_4_0_5; -.
DR   OrthoDB; 7316598at2; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001994};
KW   Transferase {ECO:0000313|EMBL:CAL78587.1}.
FT   MOD_RES         210
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   431 AA;  45536 MW;  21FA49752B8A8446 CRC64;
     MPPPKPPAFE TLSLHAGQHP DPATGARAVP IYQTTSYVFD DTEHAAALFN LERAGHIYTR
     ISNPTTAVLE ERLAALEGGV GAVCTASGQA ALHLAIATIL NAGDHIVASS SLYGGTINLL
     AHTLPRFGIN TSFVKPRDLD GFRSTIKPNT RLVIGETLGN PGLEVLDIPK VSAIAHEAGI
     PLLIDNTFAT PYLSRPIAQG ADIVMHSATK WLGGHGIAIG GVIVDGGRFD WRASGKFPVL
     TEPYAGYHGI VFDEQFGTAA FIMRARTEGL RDFGACLSPT NAFHLLQGVE TLHLRMERHV
     ANTAAVLAAL TANKAVDWVL HPSLETHPDH ALAKQLLPRG TGSIVSFGIK GGRAAGRKFI
     ESLKLISHLA NVGDAKTLVI HPASTTHQQM DAAQLAAAGI GEELIRLSVG IEAASDIIDD
     LGQALRASQK V
//