GenomeNet

Database: UniProt
Entry: A5A8Y8
LinkDB: A5A8Y8
Original site: A5A8Y8 
ID   EGFL8_PIG               Reviewed;         295 AA.
AC   A5A8Y8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   RecName: Full=Epidermal growth factor-like protein 8;
DE            Short=EGF-like protein 8;
DE   Flags: Precursor;
GN   Name=EGFL8;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The pig genome sequencing consortium;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
DR   EMBL; AL773562; CAN13271.1; -; Genomic_DNA.
DR   RefSeq; NP_001116583.1; NM_001123111.1.
DR   UniGene; Ssc.3386; -.
DR   ProteinModelPortal; A5A8Y8; -.
DR   SMR; A5A8Y8; -.
DR   STRING; 9823.ENSSSCP00000001540; -.
DR   PaxDb; A5A8Y8; -.
DR   PRIDE; A5A8Y8; -.
DR   Ensembl; ENSSSCT00000001582; ENSSSCP00000001540; ENSSSCG00000001434.
DR   GeneID; 100144521; -.
DR   KEGG; ssc:100144521; -.
DR   CTD; 80864; -.
DR   eggNOG; ENOG410IR79; Eukaryota.
DR   eggNOG; ENOG41129FY; LUCA.
DR   GeneTree; ENSGT00940000162975; -.
DR   HOGENOM; HOG000231494; -.
DR   HOVERGEN; HBG051453; -.
DR   InParanoid; A5A8Y8; -.
DR   OMA; TCSCEDN; -.
DR   OrthoDB; 749722at2759; -.
DR   TreeFam; TF331360; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Bgee; ENSSSCG00000001434; Expressed in 5 organ(s), highest expression level in prefrontal cortex.
DR   ExpressionAtlas; A5A8Y8; differential.
DR   Genevisible; A5A8Y8; SS.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   3: Inferred from homology;
KW   Calcium; Coiled coil; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    295       Epidermal growth factor-like protein 8.
FT                                /FTId=PRO_0000294929.
FT   DOMAIN       34    112       EMI. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00384}.
FT   DOMAIN      111    143       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      145    185       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   COILED      202    233       {ECO:0000255}.
FT   COMPBIAS     96    171       Cys-rich.
FT   CARBOHYD     50     50       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     38     97       {ECO:0000255}.
FT   DISULFID     65     71       {ECO:0000255}.
FT   DISULFID     96    110       {ECO:0000255}.
FT   DISULFID    115    125       {ECO:0000250}.
FT   DISULFID    119    131       {ECO:0000250}.
FT   DISULFID    133    142       {ECO:0000250}.
FT   DISULFID    149    160       {ECO:0000250}.
FT   DISULFID    156    169       {ECO:0000250}.
FT   DISULFID    171    184       {ECO:0000250}.
SQ   SEQUENCE   295 AA;  32402 MW;  CE232FE3E5714640 CRC64;
     MGSRAELHTL LGGLSFLLLL MSGQGAKGGS FKESQGVCSR QTLVVPLRYN ESYSQPVYKP
     YLTLCPGRRV CSTYRTTYRV AWREVRREVQ QTHAVCCQGW KKRHPGALTC DEAICAKPCQ
     NGGVCVRPDQ CECAPGWGGR HCHVDVDECR TGVTLCSHRC HNTAGSFTCG CPHGLVLGPD
     GRTCAEGASE PPTSASILSV AVREAGREDR ALRREIRELR GRLERLEQWA GQAGAWVRAV
     LPMPPEELQP EQVAELWGRG DRIESLSDQV LLLEEKLGAC SCEDNSLGPG LSRRR
//
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