ID   A5CYG5_PELTS            Unreviewed;       357 AA.
AC   A5CYG5;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Multidrug resistance efflux pump {ECO:0000313|EMBL:BAF60982.1};
GN   Name=EmrA {ECO:0000313|EMBL:BAF60982.1};
GN   OrderedLocusNames=PTH_2801 {ECO:0000313|EMBL:BAF60982.1};
OS   Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC   Pelotomaculum.
OX   NCBI_TaxID=370438 {ECO:0000313|EMBL:BAF60982.1, ECO:0000313|Proteomes:UP000006556};
RN   [1] {ECO:0000313|Proteomes:UP000006556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13744 / JCM 10971 / SI {ECO:0000313|Proteomes:UP000006556};
RX   PubMed=18218977; DOI=10.1101/gr.7136508;
RA   Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.;
RT   "The genome of Pelotomaculum thermopropionicum reveals niche-associated
RT   evolution in anaerobic microbiota.";
RL   Genome Res. 18:442-448(2008).
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000256|ARBA:ARBA00009477}.
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DR   EMBL; AP009389; BAF60982.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5CYG5; -.
DR   STRING; 370438.PTH_2801; -.
DR   KEGG; pth:PTH_2801; -.
DR   eggNOG; COG1566; Bacteria.
DR   HOGENOM; CLU_018816_6_1_9; -.
DR   Proteomes; UP000006556; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 2.
DR   Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   NCBIfam; TIGR01730; RND_mfp; 1.
DR   PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR   PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006556};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..349
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
FT   COILED          170..197
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   357 AA;  38848 MW;  74252E706CA7DC29 CRC64;
     MSEDLLAATG AKKNKLIVAF LFLAIIALSA LIIFSLHRRQ ASLSEERDSL TATGTVEAKN
     VTASFKVAGK IEAIFAAEGS RVEEGQELAV LEAKEITAKL NQALGAHEAA LAQARQAGES
     VPLTSQQVET AIDQARAKVA QAEVGLNDAR LLYERTAKLW ENGAVAQKSY DDAKNNYELA
     QNRLKEAQAA LDQALSARLK VQVAQAQHEA ALAQSRQAAG AVQEAQVYLE NTRLKAPISG
     YITQKFVEQG EMVNAGTPVF EITDLEHTYV KVFISEKKIG RVRLGQDAEV TVDSFPGRVF
     PGKVVWINDA GEFAVRKAVN EQYEHDIRSF EVKIDVPNPD LALKTGMTAH VRILEGR
//