ID A5DAB2_PICGU Unreviewed; 755 AA.
AC A5DAB2;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=3'-5' exonuclease domain-containing protein {ECO:0000259|SMART:SM00474};
GN ORFNames=PGUG_00217 {ECO:0000313|EMBL:EDK36119.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK36119.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK36119.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408155; EDK36119.2; -; Genomic_DNA.
DR RefSeq; XP_001486840.1; XM_001486790.1.
DR AlphaFoldDB; A5DAB2; -.
DR STRING; 294746.A5DAB2; -.
DR GeneID; 5129441; -.
DR KEGG; pgu:PGUG_00217; -.
DR VEuPathDB; FungiDB:PGUG_00217; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_3_2_1; -.
DR InParanoid; A5DAB2; -.
DR OMA; WVETESD; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 225..393
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 707..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 86259 MW; 5730715F91169F5A CRC64;
MGSSEIQVLD DAIRQSVQTI RSASSLAAQD IPFSRTLSQD LSQHLDFTSD RLKRLADEML
QLVSSSERKP NSSESSVFRK DWKGYSNKLD NIFEVVEHMF DRLNTQDPTI EAKENMLHLD
SEVHDMEAAN ALARSRIIKP QQFFKTKIDN SESAPFKPKL TSKPHALKSF EESCNLRSGA
DTEFGKDPDY FPHPYEYEID TLEYPESVLE ISEPKKPKDW TSTSAIWVET ESDLSQMVSD
LSSQTEIAVD LEHHDYRSYL GIVCLMQISS REKDWIIDTL KLRDSLVVLN EIFANPNIVK
VFHGAFMDII WLQRDLGLYV VSLFDTYHAS KKLGLPRFSL AYLLENYANF KTSKKYQLAD
WRMRPLSGPM LSYARSDTHF LLYVYDQLRN QLLSSGSQKM KEVLHESRQV AKRRFEFTRF
RPTSVSGSKV SCPIMAPNAK EPYSSIMNQF NLPNHTRPIV EALYLWRDAK AKECDESVRY
VMPNQLLVNF SLLALPVDKE TILRNPYITD QVRNSVDELV TLLNSVMQQV SDSDWALVDN
WHGSPEGGKL SSEESLSAQK IASIFETAVT EHTKALQKAF EFAEGSQLLG REDIGSVCAI
SFDLSNRQPI YHLDDEFRER TKKLESNLTN FSSPTPESTT LQSEQDHIQN DHLEKAEVKS
IVAPKKLLDN DDEIISLRKR NPNRNVEARN IAQDDVLHYS DSTILGQAKA ATKKDKKTKR
SFDPNSVDDD GPQPAKRLRR MNPGKSLTFS SHKKR
//
