ID A5DCA0_PICGU Unreviewed; 1209 AA.
AC A5DCA0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=PGUG_00905 {ECO:0000313|EMBL:EDK36807.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK36807.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK36807.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CH408155; EDK36807.2; -; Genomic_DNA.
DR RefSeq; XP_001487528.1; XM_001487478.1.
DR AlphaFoldDB; A5DCA0; -.
DR STRING; 294746.A5DCA0; -.
DR GeneID; 5128712; -.
DR KEGG; pgu:PGUG_00905; -.
DR VEuPathDB; FungiDB:PGUG_00905; -.
DR eggNOG; KOG3657; Eukaryota.
DR HOGENOM; CLU_001524_2_1_1; -.
DR InParanoid; A5DCA0; -.
DR OMA; LWLWDED; -.
DR OrthoDB; 5403095at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 672..901
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 1209 AA; 139191 MW; 1ABE7BCB7235A054 CRC64;
MRLLRRLPTR HYTSKVVSGA EKPRINELGI QYLSESLHKK VFPKTSVNDY KKKRDPARLL
LAQKHLKHNG LLDRKTNIEE PIQFPHFPSL VGNNIEEHFH KLGTSCSEPY LSMAERFLAT
KTLPKKPTKW VFESGWTRYT PGADPEAVPF PSESELVFDV EVMYHRSPFA VICTAVSSKA
WYGWVSPLLT NFAIDPSYDD WEHLIPFDCL RNPKLLVGYN VSYDRARVRE EYNIKQSQAF
YLDGMALHVA TSGISSQQRP MWHKHNKAKK TTEEESELFV QSELDQELSD DPWLNKGSPN
SLASVAKFHC GIDVDKSDRE FFETTEPQDI IDNFDMLMDY CAKDVDATFK ITAELFPRFR
KKIPHPVSFA ALRHLGTLVL PTTKKWDSYV STAEDCYLHN RQQVSEILRE RANSLVSFVE
AKEPLPDVSD DPWLRQLDWT LKEQRFKKNG EPVAKQAFLT GYPEWYRDLF RNKEKEMNIS
VRTRITPLLL KLKWEGYPLL WTDSAGWCFK VPDETKEVKR MAAKNYTLAK LSEEDHESLL
DELRDNGHYQ LFKIPHPEGP SKRCTSVLSK SYLRYFENGV LSSEYEYAQD ILRLNSEASY
WMGNRNRILD QFVVYSDTSG SKNMFFDTKV KSREHPEMGI ILPKLCSMGT ITRRATENTW
LTASNSKSNR IGSELKAMIE APQGYAFVGA DVDSEELWIA SLVGDSMFKI HGGTALGWMT
LEGDKNEGTD LHSKTAEILG ISRNDAKVFN YGRIYGAGVK FATTLLKQFN SELTDAAALK
VAQDLYARTK GQTGKSKFLD RPMYHGGTES VMFNALEAIA YQDDPRTPVL GAAITDALSK
KNLNKNNYMT SRINWAIQSS GVDYLHLLLI SMEYLIARYQ VDARLILTVH DEIRYMVKED
QKYKLALLLQ VSNLWTRAMF CEQMGLKEVP QSCAFFSEVD IDHVLRKEVT MDCVTPSHPD
SIPPGEKYTI RQLLEKCDFG KVLDEGRKKR GYKPLDYQYQ PQVPVLQALQ GGIESLSLAK
LRIQNSIDKA EWRKEVNQFI KLQKNEQLDE IERSFEKTSI SSKPRKSIKN DFDVSSDGDE
ALRHELAASA LESYDDQNHD FGDFSIPGQQ VKYVRQSAFK YNNYKPQKYD IRTKTWSAKV
SRAQKNIKEP KSTPNENRQV LGFHPFAKQR YEAKRSFSTA TKTARSVTDR RRGNAWFYWK
EAWRRPNQQ
//
