ID   A5DFD5_PICGU            Unreviewed;      1171 AA.
AC   A5DFD5;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2008, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDK37888.2};
GN   ORFNames=PGUG_01986 {ECO:0000313|EMBL:EDK37888.2};
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK37888.2, ECO:0000313|Proteomes:UP000001997};
RN   [1] {ECO:0000313|EMBL:EDK37888.2, ECO:0000313|Proteomes:UP000001997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324 {ECO:0000313|Proteomes:UP000001997};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
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DR   EMBL; CH408156; EDK37888.2; -; Genomic_DNA.
DR   RefSeq; XP_001486315.1; XM_001486265.1.
DR   AlphaFoldDB; A5DFD5; -.
DR   STRING; 294746.A5DFD5; -.
DR   GeneID; 5128142; -.
DR   KEGG; pgu:PGUG_01986; -.
DR   VEuPathDB; FungiDB:PGUG_01986; -.
DR   eggNOG; KOG3694; Eukaryota.
DR   HOGENOM; CLU_001013_1_1_1; -.
DR   InParanoid; A5DFD5; -.
DR   OMA; EIRIHAT; -.
DR   OrthoDB; 90320at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001997}.
FT   DOMAIN          122..489
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          541..770
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          946..1025
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1171 AA;  133257 MW;  2F7279892879F83A CRC64;
     MRSRSQSWSV IPTQSTPGIT RNHSFSINKP RGASGLASPS AIHPASRDPS FSAADRNRSA
     TLNSIDSLNI NSIDSIKFNN SSHDFDAAIS DSPPHESPTW ILSDLLQSFA FIKDSTDSLS
     IVTKGNDLIL LLRQYPGLKE DIVMKHLLTR IQFMFYHSVS EVRATGYRIL RYSIIDNDGL
     SLVVQFKILI FIIITMSTSN TLVEKEQALK LVREFTTIPR GIDNLSIGVV KSIIAVVESG
     DEQDVSSSFM FAGVETVCEL ALAKPELVFH AGGFQFMIQT MLDGETEAAC MCIMVLLKTL
     DCAESRKYLR GGQDLTSLLS FMSPIDSGAD DRRIPTAKLQ KIAFLITVLL KNWTGLLSVS
     HHNFRFIGDL VHNLQKRSPK LRGVIMDIIF DVLRIRALPW LESSSVGSVL NVMHTKLRTG
     SSRFAYTELE PTSLQHGFVN HYLGLLVMIF VRCGIMPLLA DLVAARDKTS EKASLLLYHI
     YHMATTLIPT DILNGYDLLP ANPELTATVM IEKRARKQVT RKSQDVKPYV KAIDNEACYN
     LDDSEFKLMV TNTRVLTVKE YEEWNWTLLS TMIKGCLRNP KRFDDIEKSP RFLKRVFSFY
     RPFKYRFCGV PTTAKNAKRY VTVGCQLLEV LLSFDAGIRY LASSKLLPQL AEALAQVDQY
     SGINAKEPIL SRKRLETTLS FGYLRFIGVL SDNPFGVRIL EQWQIFNILQ NIVDGSVSDE
     SNNYLLVNLL SRLNYRLDSQ ARILLIKSVS ISNNKVRMYL MENVVPGLLK AEECEDLSIR
     ILVDKVYDFN KDISNHAIEW LYRFSQENEY SKLDRIIEYR PSVRILQTHE FGRKLLIHFL
     NTPNGFRYLH DDGYVDRELQ NTLKAIDSNH LDKIEEILWG CFFPFSHTVS HDVIPHHFLT
     DLLQTEDGLH YFQNGPAKMY LERILQETKI MARSLIEGGH FDNTALRKLK QNLWIIGDIS
     SSEYGIQLFD SCENSSIDKT IISVILELFE KSPVWQIRGI VFLQLGRIAS TVEGIEILDE
     NKWVSTIDSH NRPQSLCFPL DISVMKVDIE NPYRDANYYA LYSGGQESLE FVDNDEYADF
     EHVKQKVLVL ISNLGSLLGR IERRARKELM LIKTGPTGRV FGDISLFLEV IKLIDKSKFA
     LPTRKFVFEL FLDTKVLESL VKRERKNSGL K
//