ID A5DIK5_PICGU Unreviewed; 380 AA.
AC A5DIK5;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=GPI-anchor transamidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PGUG_03106 {ECO:0000313|EMBL:EDK39008.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK39008.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK39008.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; CH408157; EDK39008.2; -; Genomic_DNA.
DR RefSeq; XP_001485377.1; XM_001485327.1.
DR AlphaFoldDB; A5DIK5; -.
DR STRING; 294746.A5DIK5; -.
DR MEROPS; C13.005; -.
DR GeneID; 5127154; -.
DR KEGG; pgu:PGUG_03106; -.
DR VEuPathDB; FungiDB:PGUG_03106; -.
DR eggNOG; KOG1349; Eukaryota.
DR HOGENOM; CLU_044656_2_1_1; -.
DR InParanoid; A5DIK5; -.
DR OMA; PGHTNNW; -.
DR OrthoDB; 1122658at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR GO; GO:0003923; F:GPI-anchor transamidase activity; IEA:InterPro.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR028361; GPI_transamidase.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR48067; GPI-ANCHOR TRANSAMIDASE; 1.
DR PANTHER; PTHR48067:SF1; GPI-ANCHOR TRANSAMIDASE; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500138; GPI8; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..380
FT /note="GPI-anchor transamidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027619972"
FT ACT_SITE 159
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 201
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 380 AA; 43843 MW; 6DA26F40FD89CC79 CRC64;
MKIVTLWIWV FLAALGRASD SGPDHVLEND INNDSHHTNN WAVLVSTSRF WFNYRHMANV
LSLYRTVKRM GIPDSQIILM LSDDIACNPR NAFPGTVFNN MDQAIDLYGE SVEVDYRGYE
VTVENFVRLL TDRWDSNHPR SKRLMTDENS NIFIYLTGHG GNEFLKFQDA EEIGAYDIAD
AFEQMYEKKR YNEIFFMIDT CQANSMYERF YSPNILAVGS SKVDESSYSH HSDLDLGVAV
IDRFTYYTLE FLEKIDKNSN VTMDKLFDEY TFENVHSTPG IRTDLFRRNV SEVRLTDFFG
NVQDMEVDTA QDEKIMHIMN EVHKQEAQES PRESQAEVTF KSTYGKLDER TALVKVSGTQ
KRLIAGFTAC VLVGLWVIAK
//
