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Database: UniProt
Entry: A5DKW3
LinkDB: A5DKW3
Original site: A5DKW3 
ID   DRS1_PICGU              Reviewed;         705 AA.
AC   A5DKW3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   16-OCT-2019, entry version 60.
DE   RecName: Full=ATP-dependent RNA helicase DRS1;
DE            EC=3.6.4.13;
GN   Name=DRS1; ORFNames=PGUG_03914;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM
OS   1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC   Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L.,
RA   Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S.,
RA   Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J., Harris D.,
RA   Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E.,
RA   Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J.,
RA   Santos M.C., Schmitzberger F.F., Sherlock G., Shah P.,
RA   Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I.,
RA   Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W.,
RA   Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH408158; EDK39816.2; -; Genomic_DNA.
DR   RefSeq; XP_001484533.1; XM_001484483.1.
DR   SMR; A5DKW3; -.
DR   STRING; 4929.XP_001484533.1; -.
DR   PRIDE; A5DKW3; -.
DR   EnsemblFungi; EDK39816; EDK39816; PGUG_03914.
DR   GeneID; 5126441; -.
DR   KEGG; pgu:PGUG_03914; -.
DR   eggNOG; KOG0338; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   InParanoid; A5DKW3; -.
DR   KO; K13181; -.
DR   OMA; HEPERSW; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    705       ATP-dependent RNA helicase DRS1.
FT                                /FTId=PRO_0000294642.
FT   DOMAIN      229    405       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      416    588       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     242    249       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED       97    178       {ECO:0000255}.
FT   MOTIF       198    226       Q motif.
FT   MOTIF       352    355       DEAD box.
SQ   SEQUENCE   705 AA;  79595 MW;  7398C4D6664B1B1B CRC64;
     MHRYCRVGFR DEHRISHLTA STMAKKHRDD FVMTIDSDSE ASDGGDSDTE QKTGDLNPDF
     VFGEAEETAF TGWDLDQKDV ANHKDVDLDG ILRSKGGLSG MIDGEEEEQK EEEEENEDNA
     EDEEEVNAGE DDEDLAMDGF GMGAEQEDDE EEENSEQENE HEAESEDEQE QEISENDEDS
     AAAIAEFYEE SKTTEKITSF QALQLSRPLL KGVGNLGYTV PSAIQAASIP IAMMGKDIVA
     GAVTGSGKTA AYLIPIIERL IYKPAAVSAT RVIVLTPTRE LAIQVCDVGK KLGQFVANLN
     FGLAVGGLNL RQQEQQLKSR PDIVVATPGR LIDHIRNSPS FSIENLEVLV MDEADRMLEE
     GFQVELTEIL ELIPKHKRQT MLFSATMNTK IQDLIQLSLD KPVRIMVNPP KQAASKLVQE
     FVRIRKREHL KPALLYHLLR LVDPQQQNRI VVFVSRKEMA HRLRIVLGLL GMKVSELHGS
     LTQEQRLQSV KDFRSLAVPV LICTDLAARG LDIPKIEIVI NFDMPKTHEI YLHRVGRTAR
     AGREGRSITF VGESNQDRSI VKDAIKSLEE QKNGKAVSRT VDWKKVEELN SIVESKKDTI
     DEVLEEEKSA KEILQAEMQL EKASNIMKHE KEIHSRPKRT WFQSEQEKKQ AQRTPVMQSL
     TKHGKKVNSK KRKAHEERKE EKRSYKKTKS DRSAPKTKAK SKKRK
//
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