ID A5DM35_PICGU Unreviewed; 1426 AA.
AC A5DM35;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PGUG_04336 {ECO:0000313|EMBL:EDK40238.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK40238.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK40238.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; CH408159; EDK40238.2; -; Genomic_DNA.
DR RefSeq; XP_001483607.1; XM_001483557.1.
DR STRING; 294746.A5DM35; -.
DR GeneID; 5125591; -.
DR KEGG; pgu:PGUG_04336; -.
DR eggNOG; KOG0951; Eukaryota.
DR HOGENOM; CLU_000335_1_0_1; -.
DR InParanoid; A5DM35; -.
DR OMA; QTEIQYY; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997}.
FT DOMAIN 457..641
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 676..886
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..198
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 162243 MW; EF7F6AD75A54C00E CRC64;
MSYNQYKYEE MSNMVLKPGR RPREEISDAP SSLSGRISVK EMGSRVERVK PTSENDQERP
SKNPSTTKSD GYAPEVSTEV SYYPTTAENG HIFELLMTSV NTILPDSSHE VILSAADAVL
DICKQQDVNN KQKQSEIEAL LETKLDSNAF DEILKLCNRI TDYDAREENE ETEENLDGVP
IVFDEEDEED ENPQDSEEED DKIVGPSIEP NDQDSSLVGS NDITVKTETT QSASESNIIP
LHEIDQYYLQ RRLAFIYGDE NASETQTMAE KMNKLLQNAD LSTRDLENEL MEILDYDHFD
LVTFCLENRW RLVYKMKLLD GVDETKVYDE MRSLNLHGLV DEFQGVRQSS KRRLSDSETS
VKKQKKISTK RQPREVDLSA LAFDQGSHMI STNRVKLPPG SYQQKKKSYD IISIPAPTPA
EDNDPLISIS ELPSWAQEVF PSSETTNLNR IQSKIYPSAF KTDENLLLCA PTGAGKTNVA
MLTILRTLEH YRKEDGRFDL GEFKIVYVAP LKALVQEQKR EFERRLTPTF GITVNELTGD
SSLSAQQISE TQIIVTTPEK WDVITRKGSE VPHVSLTRLV IIDEIHLLHD DRGPVLESII
ARTQRQMESS GEPIRLVGLS ATLPNYKDVA KFLRVDFEKG LFYFDATYRP CPLEQHFIGI
KEKKAIKKVQ AMNEACYDKM IESLESKHQI IIFVHSRKDT YKTAVWLRDK LVENEKLNLV
QTTAGSKEIL RQEAEAVRNQ NLAEVIGGGF GMHHAGLNRD ERSLVEDLFA QGHIRVLVST
ATLAWGVNLP AHTVVIKGTE TYSPELGSWV QLSPQDILQM LGRAGRPRYD KSGEGVIITS
SDDIQYYLAI LNQQLPIESQ MMSKLVDIIN AEVVLGSVTT RQQVVEWLSY TYLYIRMLRA
PALYRVGADY ADDKLLSDKR EDLSHSALQI LHRHKMVQYD MESGAIKSTE LGKIASHFYI
GYETISAYNN NLKSWSTIVD VFRIFCMSGE FRLIPIRQEE KLEVTKLAQK CPIPIKEAAT
EPIAKVNVLL QTYISRLSLD GFALVADMVY ITQSAGRLFR ALHEIALKKK WSAIARTTLD
VCKMVERRMW LVNSPLRQFG ELASPQIIRA AEGSHLPWNS YFDLEASELA EAIAFKGNSQ
KVHQLLQQFP RNKMDYLLQP ITSKMIRVQF EIVPNFNWNV NLHGNSQRFL LLIEDCDGET
ILFSDNFTVY RRNAQKPHII EAAVPFMDPE QPQYFASVIS ESWINCETRI PLMLNNIQVP
KKGSSFTELL DLHSVETSEL KNEAFSKCFD FRYFNRFQSQ AFNALYWTSH NVLVGMSKNN
GKTVCAELAV LAHWRAGGGR IVYLNPNLEK LKRVGKSWSK RFHGLTDPPK EINCLSGDPT
VDLALLSSSH LVLATPDQWD RISRRWKQRR AIQSVDLYVA DRCTFG
//
