ID A5DMG0_PICGU Unreviewed; 604 AA.
AC A5DMG0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=VHS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PGUG_04461 {ECO:0000313|EMBL:EDK40363.2};
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746 {ECO:0000313|EMBL:EDK40363.2, ECO:0000313|Proteomes:UP000001997};
RN [1] {ECO:0000313|EMBL:EDK40363.2, ECO:0000313|Proteomes:UP000001997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL
RC Y-324 {ECO:0000313|Proteomes:UP000001997};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408159; EDK40363.2; -; Genomic_DNA.
DR RefSeq; XP_001483732.1; XM_001483682.1.
DR AlphaFoldDB; A5DMG0; -.
DR STRING; 294746.A5DMG0; -.
DR GeneID; 5125099; -.
DR KEGG; pgu:PGUG_04461; -.
DR VEuPathDB; FungiDB:PGUG_04461; -.
DR eggNOG; KOG1087; Eukaryota.
DR HOGENOM; CLU_017092_0_0_1; -.
DR InParanoid; A5DMG0; -.
DR OMA; PDNYEPN; -.
DR OrthoDB; 460229at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0016482; P:cytosolic transport; IEA:UniProt.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd14235; GAT_GGA_fungi; 1.
DR CDD; cd16998; VHS_GGA_fungi; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47180; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR PANTHER; PTHR47180:SF1; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001997};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 66..202
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 229..358
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 489..604
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 426..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 67287 MW; DDC015E3F541574E CRC64;
MPCNAPCITV TPRISKLPAE QIPWEDACIG CVLIDTCILD VDLRIMPNRF RSPSNDFLLP
TNSDRACRPT LNEPNLALNL EICDYVNAKQ GSTPREAAIA VVKLISQKDP QTSELALALL
DNLVKNCGYP FQLQISRKEF LNELVRRFPE RPPLRYTRVQ RMILAQIEEW YQTICCTSKY
RSDFGYIRDM HRLLANKGYV FPELNLDDAA VLNPSDNLKS LEELQNEESV VNSAKLQEFI
RRGRPQDLQE ANKLMKIMAG FKEDNVEANK KQVTNDVARL KRKTEILAEM MNTMEVNGGN
IDSSDETLSD LYGSVKSSQP IVTKIIEEGN GDEEYVQELL QLNDVINSLV NKFQLLKGGK
TDEASKIKVS GVSTGSNDLN LIDFDDDAPI SNDQTGKDNQ GYQDLLSDLS NLAFTDTGNS
QNIFGTGGSI TLGMNSQPTP PSQSNSIQHP TPVSNFDLLS DLNSPSPQLQ SNTSAKLDPF
NFDTSSLSFA NSQSSQLKQL HVSPTLKSEV QMAVNGTTHS GKFLFSNPQA AAITNFKFLV
AVPKSCKLTL QPQTGDVIYP FTTHSVSQEF SIENPMSKQL RVKWKVEYRV NNEHKEETGV
TILD
//
