ID A5DV92_LODEL Unreviewed; 1130 AA.
AC A5DV92;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 22-FEB-2023, entry version 82.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN ORFNames=LELG_01278 {ECO:0000313|EMBL:EDK43100.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK43100.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK43100.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CH981524; EDK43100.1; -; Genomic_DNA.
DR RefSeq; XP_001528758.1; XM_001528708.1.
DR AlphaFoldDB; A5DV92; -.
DR STRING; 379508.A5DV92; -.
DR GeneID; 5235374; -.
DR KEGG; lel:LELG_01278; -.
DR VEuPathDB; FungiDB:LELG_01278; -.
DR eggNOG; KOG2051; Eukaryota.
DR HOGENOM; CLU_002633_1_0_1; -.
DR InParanoid; A5DV92; -.
DR OMA; DFQHHQI; -.
DR OrthoDB; 276824at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 2.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 36..267
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 396..583
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 602..821
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 785..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..1005
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 130182 MW; F31BE8CA024CA937 CRC64;
MTVELDGRRK ELLELNLKSW ENEYTLPVAT KLDSSLKKNT AFIKKIKTSL NHDQLKNILS
DIKSLSLEKY LSEVIVSLVE GMVKVSKSDD IAATMEICSA FHQRFGVDFT GDMMNQVLVY
MLNHRDQDAA DDEKATQQII SRQKNLLRLM GEFYAVKIIR TGSDILSSID PKIVKLYNLD
KKRNEPLITL LLKYLLNFDL EQGRCLSAVH SFLKRFRHLI FDLENDILDS EVKHVLKQIF
TIYTEATLKV AVELKNKVGK LQVRNKKASI RTGRILEEEE LELQEATILF ANFKQTLEFL
APLVDVSLPS TILDADLLDD TNGNELEISN ENTVEVVKQK SSGMEEDAYG IWEDAKEKAF
YTIIPLLEEL LSSMQKEQGE ETLSKRENLD ESQSSGGKIQ DFLNRLEDVR SNDMDQLVVE
FNNLQLNNKA TRNRIMRFFI ETSTLNNLRY YTRFLKINES NLKELIEDLI TYLDNGFRSQ
LHRNKLNVKN ILFFCELVKF KMIPIHVIFH KIRRLTLDIT STNNIEILSV FYENVGRFLL
HEPEYKDLMR GMIDLLKEKL KQSNLKVNDK LAINNLLIMV EPPAVKVQRE VIELSPKLQF
VQKLIRSELN KNTILLISRL LKKVFASNVG EEESQALLDS FARPDLLNYD NLPALAKLLH
TFADKRVIVI IVDTIVENII RGLELNDFRM NRARMSQVKY IAEMYNHGLL NYKLINDLLY
RILCYGHPQN QPLPNNWDID IDLPNNYFRI QMCCLLLLSL QSVHVEILPL LKKNTNKAKA
RAKAKARAKG KGKGKGKANM ADTAGADTDY ENEDAEFKKR KEVNENLLSV FVTFFQYYMY
CKEAPFPVDV KFKLDDMFKK FENVPGVIRY ESVRDVVKKL AELIQTKEDA ETYLENEEEN
ASEPLGDDED DEDEDDEDDE EDDVDDEEDD EDDNEDEDIE IDPEEEEDDD EEEEVGETDS
EEGDSDSDEE DSESDDDETD SEDEEDEDEE DDIDFSDVSD DESLPDAMSE LEKERIEAEK
KFQSDLDKEF QRIMIESYGT STQGQVGNTR KPLPAPGQLF QENQNRPNVA SNGKIKFGLL
TKSGAGGKTN TVKQLHLPSD NKFAESVLRE QENRKRDRQR IMSLASQMGD
//
