ID A5DWC2_LODEL Unreviewed; 913 AA.
AC A5DWC2;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN ORFNames=LELG_01658 {ECO:0000313|EMBL:EDK43480.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK43480.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK43480.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH981525; EDK43480.1; -; Genomic_DNA.
DR RefSeq; XP_001526830.1; XM_001526780.1.
DR AlphaFoldDB; A5DWC2; -.
DR STRING; 379508.A5DWC2; -.
DR GeneID; 5234370; -.
DR KEGG; lel:LELG_01658; -.
DR VEuPathDB; FungiDB:LELG_01658; -.
DR eggNOG; KOG1281; Eukaryota.
DR HOGENOM; CLU_005170_8_0_1; -.
DR InParanoid; A5DWC2; -.
DR OMA; GYGLMYI; -.
DR OrthoDB; 5485124at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR CDD; cd01115; SLC13_permease; 1.
DR CDD; cd14478; SPX_PHO87_PHO90_like; 1.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10283:SF92; LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91; 1.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR Pfam; PF03600; CitMHS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..340
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 128..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..190
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 101343 MW; 14D395A50A7F21F0 CRC64;
MKFSHSLQFN AVPEWSSKYL AYTTLKKLIY SLQRDSLRRR HQQGTGIDED LEENAQLVGE
HYSSLGNLVE NPQDESAVTV FEAALNAELK KIDTFFKQQE QFIFKSIDEL VFDIEEFEKE
IDASLQSHTL PKPRRNRGRR FSDISNDNYF TTDPETEYTQ AEEADANEVG DNEDEDDDED
EDDPENDENE NENGNGNGIV NLVDRGNRNN STEELSERRN SFPRPRGRQV KRMESAPNIH
TEHSETGLTH TKSIDEYLRS PNAPKLWNEL SNATDNDGRL PPQLILLTES RIIMRKRTIG
LYTTLSELKS YIELNYTGFK KALKKFDKSL DTNIKDEYLA NLPNSSYIFK QSTMEKVDAK
LESLVKVYAL ICNHGDDLAA AKSELSIHLR EHVVWERNTV WRDMIGLERK TYAANSKLVD
KRERAAGDKE GELKGSGGLT HSFNLSWRNP VFIKLAITTT VTVILLNFSP FGDEAQKNCF
ALLICASLLW ATEAIPLFVT SLLIPLLVVL LGVVKNTDGS IMDSVLASKY ILSTMWNSVI
LLLLGGFTLA AALSKYHIAK LISTWILSKA GTNPSVVLLT IMGVALFASM WVSNVAAPVL
CFSLIQPLLR TLPKGSQFIN ALVLGIALAL NIGGMASPIS SPQNVIALGA MDGGISWGQW
FVIALPVCVL SLLLIWMLLL LTFNCNSKNT HLLPIRTIDD KFTGIQWFIV AVSVGTIFLW
CIASKLTGIF GEMGIIALIP LILFFGTGLL TTEDFNNYPW NIVVLAQGGA CLSSAVSSSG
LLKTIALELR NQVEGFSLYG VTLTFALIIL VMATFISHTA AALIFIPIIK ETGQSMPDPH
PNLLIMVSCL ICSGAMALPT LGFPNITAIC MTDQWGRPYL DVVMFITRGV PLSLIAYAMI
VTVGYATMKI INF
//
