ID   A5E0F0_LODEL            Unreviewed;      1229 AA.
AC   A5E0F0;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   13-SEP-2023, entry version 62.
DE   RecName: Full=Pre-mRNA-processing-splicing factor 8 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LELG_03087 {ECO:0000313|EMBL:EDK44908.1};
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK44908.1, ECO:0000313|Proteomes:UP000001996};
RN   [1] {ECO:0000313|EMBL:EDK44908.1, ECO:0000313|Proteomes:UP000001996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC   NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; CH981527; EDK44908.1; -; Genomic_DNA.
DR   RefSeq; XP_001525159.1; XM_001525109.1.
DR   AlphaFoldDB; A5E0F0; -.
DR   STRING; 379508.A5E0F0; -.
DR   GeneID; 5232326; -.
DR   KEGG; lel:LELG_03087; -.
DR   VEuPathDB; FungiDB:LELG_03087; -.
DR   eggNOG; KOG1795; Eukaryota.
DR   HOGENOM; CLU_000380_1_0_1; -.
DR   InParanoid; A5E0F0; -.
DR   OMA; WICMRRE; -.
DR   OrthoDB; 246127at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR012591; PRO8NT.
DR   InterPro; IPR012592; PROCN.
DR   InterPro; IPR027652; PRP8.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR   PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR   PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR   Pfam; PF08082; PRO8NT; 1.
DR   Pfam; PF08083; PROCN; 1.
DR   Pfam; PF10598; RRM_4; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT   DOMAIN          203..351
FT                   /note="PRO8NT"
FT                   /evidence="ECO:0000259|Pfam:PF08082"
FT   DOMAIN          547..955
FT                   /note="PROCN"
FT                   /evidence="ECO:0000259|Pfam:PF08083"
FT   DOMAIN          1140..1227
FT                   /note="RNA recognition motif spliceosomal PrP8"
FT                   /evidence="ECO:0000259|Pfam:PF10598"
FT   REGION          1..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..44
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..124
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1229 AA;  141502 MW;  8B9E3023A1CE19DF CRC64;
     MSRKNSSRPA PPPPPPHPRP KPPPPPPPPS RPLVSAPVPP SLGQPPAKKR LTGPNAEDSA
     GPSPPPTIAR NTGSTSTSSK HHPLPSGSVH LQTSSSSSSS SLPSHKYKPS NTPIPPPPPP
     PSAVAAQRRE KYSPLLNSSN NGNHNHVLST KAVGVASSKV VKTKVSENEL QSRRRKWNNV
     QKRRFQNSNM QASNQNGFTR PMEMPPQHLR KIISDHADMT LLKVTSDKRS HLGSLKYLPH
     ALFKLLENIP HPWELSKEVK VLYHRTGAIT FVDQSPRVIE PVYIAQWATV WELMRKEKRD
     RKHFKRMQFP PLDDEEKFLS WIENFDDADL PDAIQSTELE ADQFVGDWIY DEKPLIEENE
     IVSGSSYRKW RLDSSTMSRL FQLSRPLLLG SSDNYDVNEL ITAKSLSVAV RDGPKFEALY
     KKQIQSMDDD YSDLNSLDSV IVRHPVKSEQ RVDFPYVYNS FVKRVRTSPF QQQVISVDGR
     ETFEGASVNG YGFNSQLNPV KARKVRSKST VAIRDKPEAI KVEEVKAPVV PFSKTFGDFS
     KSEIHTLNAG LSLVSAPYPF CYRTGRTKRA EDVPLTKRWN LNLRQYNKGP VPLKTRISYQ
     KLLKNRVLNH LRHLKQKKVK HASRSTLLKK LKLTKYFQQT NIDWVEAGIQ VCQQGFEMLN
     LLLHKRGLTY LHLDYNFNLK PTKTLTTKER KKSRFGNAFH LIRELLRAIK MIVDAHIQFR
     LGNADAYQLA DGLNYIFNHI GQLTGIYRYK YKVMHQIRQC KDYKHIIYHR FNKVIGKGPG
     CGFWQPSWKV WIFFLRGMIP LLERWLGNLI VRQFEGRRYN DYAKTITKQR VDSYYDLELR
     AQVMHDILEI IPEGMKQSKS KTILQHLSEA WRCWKANIPW IVPGLPEPIK NIIERYIKAK
     AEGWISVTHY NRERIKKGTH VEKTVVKKNL GRMTRLWVKR EHNRQEDFGR QGPAISPDEA
     VKVFQTAVEW LERRNFSPIP FPPVSYKHDT KILLLALENL KSTFNANAKL NTLQREELAL
     IEQAFDNPNE CLARIKKQIL TQRIFKEVGL DMMDFYDSII PSYEVDPLEK IADAYLDQYL
     WYEADKRNLF PNWIKPADDE IPQLTVYKWC HGINNLNDVW STSNGESVVM MELTLREILE
     NVDLTLLNRL LRLVVDTNIA DYMTSKNNVN IRYKDMNYVN QQGVVRGIQF ASFLYQFYGL
     VMDLLILGTE RASELAGPVQ NPNQLLTVS
//