ID A5E0V2_LODEL Unreviewed; 214 AA.
AC A5E0V2;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
GN ORFNames=LELG_03239 {ECO:0000313|EMBL:EDK45060.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK45060.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK45060.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0007829|PDB:4EXJ}
RP X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).
RA Patskovsky Y., Toro R., Bhosle R., Zencheck W.D., Hillerich B.,
RA Seidel R.D., Washington E., Scott Glenn A., Chowdhury S., Evans B.,
RA Hammonds J., Imker H.J., Armstrong R.N., Gerlt J.A., Almo S.C.;
RT "Crystal structure of glutathione s-transferase like protein lelg_03239
RT (target efi-501752) from lodderomyces elongisporus.";
RL Submitted (APR-2012) to the PDB data bank.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000710};
CC -!- SIMILARITY: Belongs to the GST superfamily.
CC {ECO:0000256|ARBA:ARBA00007409}.
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DR EMBL; CH981527; EDK45060.1; -; Genomic_DNA.
DR RefSeq; XP_001525311.1; XM_001525261.1.
DR PDB; 4EXJ; X-ray; 1.64 A; A/B=1-214.
DR PDBsum; 4EXJ; -.
DR AlphaFoldDB; A5E0V2; -.
DR SMR; A5E0V2; -.
DR STRING; 379508.A5E0V2; -.
DR GeneID; 5232782; -.
DR KEGG; lel:LELG_03239; -.
DR VEuPathDB; FungiDB:LELG_03239; -.
DR eggNOG; KOG0867; Eukaryota.
DR HOGENOM; CLU_011226_6_0_1; -.
DR InParanoid; A5E0V2; -.
DR OMA; DWYLKLN; -.
DR OrthoDB; 1404190at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR44051; GLUTATHIONE S-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR44051:SF8; GLUTATHIONE S-TRANSFERASE-RELATED; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF13409; GST_N_2; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4EXJ};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 1..81
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 90..214
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 214 AA; 25054 MW; B2821666AA76B071 CRC64;
MAILYTGPTG NGRKPLVLGK LLNAPIKVHM FHWPTKDIQE DWYLKLNPAG IVPTLVDDKG
TPITESNNIL LYIADTYDKE HKFFYSLKQD PKLYWEQNEL LFYQATQFQS QTLTIANANY
QNGHIDENIA QYVLSSFEKV FAFMETKLSG RDWFVGDKFT IVDIAFLVGE HRRRERLHNS
PIWIDLKENF PNVEKWFQRA IAFENVEEIL KEHA
//