ID A5E1X1_LODEL Unreviewed; 990 AA.
AC A5E1X1;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Exosome complex exonuclease RRP44 {ECO:0000313|EMBL:EDK45429.1};
GN ORFNames=LELG_03608 {ECO:0000313|EMBL:EDK45429.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK45429.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK45429.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH981527; EDK45429.1; -; Genomic_DNA.
DR RefSeq; XP_001525680.1; XM_001525630.1.
DR AlphaFoldDB; A5E1X1; -.
DR STRING; 379508.A5E1X1; -.
DR GeneID; 5232452; -.
DR KEGG; lel:LELG_03608; -.
DR VEuPathDB; FungiDB:LELG_03608; -.
DR eggNOG; KOG2102; Eukaryota.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; A5E1X1; -.
DR OMA; VKVHMDS; -.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EDK45429.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:EDK45429.1};
KW Nuclease {ECO:0000313|EMBL:EDK45429.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 82..195
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 521..855
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 323..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 111954 MW; 4B1292C95564DAE9 CRC64;
MSVVNHRKRL SSGLSVTSKV FVRSRNGGAL KIVREHYLRN DIPCYSLACT ECQHIIKPDA
SGELPKFILS STPAKTIDKK PHYVVLDTNI VLHAIDLLEN TQVFYDVIVP QTVLEEVKNR
SFPIYQRLRN LVKLEDKRFI VFHNEYNEAT YINRNKNESI NDRNDRAIRK VVSWYKGHLP
KIEIVYVCND ADNRNKAKAD GLNVKSLLEY MEILPNGEDL KDLIPTDFSR TDLEKGYDET
SFPEYYSNAR IMAGIKNGTL YQGILNISTY NYLQGEVNIP AFKKPLLIQG SKNLNRAFNS
DSVIVELLPK DKWKEPSTTI IEETAIGSND NADDGDDDEV NGPTGASRGI ISDKERLLLA
QEAMKTTRGS GGSGDEKRLQ PTAKIVGIMR RSWRYYVGQI APSSVNAEDT GNTAKSCFVI
LMDKTLPKIR IRTRKAKEYL GQRIVVVVDS WPSDSKYPNG HFVRALGDVE SAEAETEALL
LEHDVEYRPF SKNVLDCLPK EGDNWVVPDI TNTTDKQLQK RVDLRDKLVC SIDPPNCVDI
DDALHAQKLP NGNFEVGVHI ADVTHFVKAG TALDQEGASR GTSTYLVDKR IDMLPMLLGT
NLCSLKPFVD RFAFSVIWEV DAEANIINVK FMKSIIKSRQ AFSYEQAQAR IDDATQKDEL
TESMRILLRL SKKLKQKRID AGALNLASPE VKVYMDSETS DPQEVEIKKL LETNSLVEEF
MLFANISVAR KIYDAYPQTA MLRRHAAPPA TNFETLNDML NVRKNGLSIS LESSKALADS
LDRCIDPTDP YFNTLIRIMS TRCMMAAEYF PSGSYGYPEF RHYGLAVDIY THFTSPIRRY
CDVVAHRQLA GAIGYENLDL SHRDKHKMEM IVKNINKRHR NAQFAGRASI EYYVGQVMRN
NESEQEGYVI KSFNNGIVVL VPKFGVEALI KLDSMGDVNS ASYDEDKYEL KFVDFEGKNR
TVGVFDKVKV DVKSIKDEVS GKRKVHLVLK
//
