ID A5E274_LODEL Unreviewed; 1426 AA.
AC A5E274;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 08-NOV-2023, entry version 83.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LELG_03711 {ECO:0000313|EMBL:EDK45532.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK45532.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK45532.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; CH981528; EDK45532.1; -; Genomic_DNA.
DR RefSeq; XP_001524679.1; XM_001524629.1.
DR STRING; 379508.A5E274; -.
DR GeneID; 5231793; -.
DR KEGG; lel:LELG_03711; -.
DR VEuPathDB; FungiDB:LELG_03711; -.
DR eggNOG; KOG3508; Eukaryota.
DR HOGENOM; CLU_002973_1_0_1; -.
DR InParanoid; A5E274; -.
DR OMA; WFVGLNY; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd05137; RasGAP_CLA2_BUD2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT DOMAIN 496..629
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 732..994
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 99..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..874
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 157367 MW; 530032F8B4693F4D CRC64;
MTFQSAFHKN IYNKRGTFEG SNFLISTDSV NWLHVKSLSI TELGQLFSTD EQENHYLLLQ
ALQSCYVQIC PNSQSLNTQR QQQQPQLVHL HLQQLLSTST LSGRESSTSR RRSRGLGSRK
NTNNNKLSSD GNASNNTGNP PEEDPPIIFI KTFENDKLYI KVASKANFGN LISTLIVWQN
LKPQGLAKKW YSENKVTNQK SSSSSSPLDG DISSSPHELL VCRFKIYGPL PNKSKNLNII
PGPVAPIYQP KIDDHLYNKW GSENHAQSPH ADYNRNNNIN EGWFYTMGAL NSNGILNFIT
ELDGTLLYSI DIKKIFASEI REVHNSIFNS SNVLFIGQLN ELRCNNVIRT TSATSNAAAS
STSGASLSSS SSTSTLGGVG GGVGGGSIGG GGGVGGSIVG GGGGSGVIGG FGSASMAADP
LSSIFLTRDG KIIPSNNRIF IEFPLHIDLE DWFVGLNYFA KREYIGSFNN EARLLTSDKK
KGGINAGAGT GKEEEYMPPP RISDFSKANF RVSKKVTIDI IEAKFDHSSL AAATKSGSTA
MGGGKIYAEV RMWGYPWSRT AIVNHTLNPF WKEEFLTNLP ISTQMIHIII KKCAYNDGTS
YSANDKVIGT VYVTPDILTK HIKTSSTIMT AHESNGIQVN NSIPLANSSL NNGLNNGLNS
ALTNNGASTL DIVRLTIYDP SNIPIGKLLL QVNLKEFHIL SSPNFKSLEF LLKNGPIDQL
VNFFNENVAA SEFERISVIL LDIFQCLHQE ERFFKTLMEM SLSSLGNKLA TQSKSTSQNN
VFNTLFRGSS IFSKALERYN IRIGQEYLEK VFGDFFAKIN KECKNCEVDP RYVKIQERAA
RKGLLNKDND LTDLDDLCGS SDDDDDDDGD GNGNGYDSEL EREKDERIKK MVEDNYQNLY
GYAEEIWHKI YITSNDIPEQ IKLQLKNFRT KVELVCEPND KVTSLNCISA FIFLRFFCPA
ILNPKLFYLT KNHQTGSTQR TLTLIAKILL NLANRQEFSP HKEPHLVKMN SFLRKHQSEV
YDYFDKITGR KNDFNEKILD LSHEVKRFDL GLDETSNELP TTPYLIDKYL RLTELVHLLN
YNTVAAQKIL NESANASQMG TPFASPLKNI EPTSTKTNHT VSSVSSHAHS QLSELDPIKF
GDADDNVGGV GGEGGEGGYG EVDFHLGNLS ALPPPNENVY QIGSLEFEKL EFLDLAGDKE
TEGFIKSLCN GNEEIFSFIN INISLKDIQM QSTKIMNKIN DLETYLENYE FPSNYTSSKT
VGDLLWGTFT DDVLDRACLD LTRNVIVSLD YNPVSLFGGG GGGNGGTNSG SNSGGNGASG
DGSLHRNHHY HHHHHYGNPN YKFIVDDNAL TLLKLKFPEN SGTGYGVGHR QTASISSLTL
SSKASGRSGR GVGIARSDDS STNFNNGSNG LDRMRDTLKK WLGRGR
//
