ID   A5E6U0_LODEL            Unreviewed;       674 AA.
AC   A5E6U0;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=DNA polymerase epsilon subunit B {ECO:0000256|ARBA:ARBA00016011};
DE   AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|ARBA:ARBA00032930};
GN   ORFNames=LELG_05329 {ECO:0000313|EMBL:EDK47148.1};
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK47148.1, ECO:0000313|Proteomes:UP000001996};
RN   [1] {ECO:0000313|EMBL:EDK47148.1, ECO:0000313|Proteomes:UP000001996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC   NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000256|ARBA:ARBA00009560}.
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DR   EMBL; CH981532; EDK47148.1; -; Genomic_DNA.
DR   RefSeq; XP_001523483.1; XM_001523433.1.
DR   AlphaFoldDB; A5E6U0; -.
DR   STRING; 379508.A5E6U0; -.
DR   GeneID; 5230575; -.
DR   KEGG; lel:LELG_05329; -.
DR   VEuPathDB; FungiDB:LELG_05329; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; A5E6U0; -.
DR   OMA; PEDGAWF; -.
DR   OrthoDB; 166885at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR   PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001996}.
FT   DOMAIN          372..628
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
SQ   SEQUENCE   674 AA;  76632 MW;  BAD7050F79E3FDA5 CRC64;
     MSIGLVKKNK TATSLPIKLL PSNLRPIVFR TLTKKHGLNV NSEALAMLTD VISQKFGFDW
     RSIQSQQFLE EIAKFWKLED RGIFVDAEGL KSVMKEINLK EEALRVQKAG RTDTIVDDQI
     TEDEIQIQWQ DYFKIVSPNE QPRCTFDKTR KQFIVTLRKE KMPLLASLSL NQRACVESKN
     NQYHLIMDRL SRNESFQKVS MTSISNLHSI SNNNGGMFFN NEITLIKNVL GRDGQRFLLF
     GLLSKDSAGE FILEDSTDYI ELNLAQTVKN QSSFYSPGMF VLVEGIYSAS GGNSSLNQDY
     IGGCFYVSNI AHPPAERRDK SLEAYGLVDF LGVHRHIASA NGGDRAIKIP KPYKKKLSQL
     EKSLTNHKIV FMGSDLYFDS PKVINGLTKF LQRLENSIIE EQDGDGERKT PLALVLTGSF
     SSKPLTSTTS SATSISNSEH YKGLFDSFTN LLANYPNVVH TCKIVLIPGD NDPWQSTFSL
     GSSCLNVIPR ASIARVFVNR LEKLLPRGNL ILAWNPCRIN YLSQEIVVFK DQLMSKFKRN
     DIVFPQDLEL EKDPLEGLND KERIDQLIQR KDEHVSSKIK QARKLVKVIL DQGTLLPFEK
     SLKVVNSQYD YSLRLEPLPN IIILHDTSFD NFEVTYQGCR VVNIARAMNQ GSRKLNYVEY
     YPSSKKFDFK DLYF
//