ID VIUA_VIBC3 Reviewed; 687 AA.
AC A5F661; C3M3G8; Q00964; Q9JQ00;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Ferric vibriobactin receptor ViuA {ECO:0000303|PubMed:1317381};
DE AltName: Full=Vibriobactin uptake protein A {ECO:0000305};
DE Flags: Precursor;
GN Name=viuA {ECO:0000303|PubMed:1317381};
GN OrderedLocusNames=VC0395_A1803, VC395_2327;
OS Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS O395).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=345073;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395
RC {ECO:0000303|PubMed:1317381};
RX PubMed=1317381; DOI=10.1128/jb.174.11.3729-3738.1992;
RA Butterton J.R., Stoebner J.A., Payne S.M., Calderwood S.B.;
RT "Cloning, sequencing, and transcriptional regulation of viuA, the gene
RT encoding the ferric vibriobactin receptor of Vibrio cholerae.";
RL J. Bacteriol. 174:3729-3738(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Liao W.J., Choi M.H., Butterton J.R.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA Heidelberg J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Involved in the uptake of iron in complex with vibriobactin,
CC a catecholate siderophore synthesized by V.cholerae. Binds and
CC transports ferric vibriobactin across the outer membrane
CC (PubMed:1317381). The energy source is provided by the inner membrane
CC TonB system (Probable). {ECO:0000269|PubMed:1317381, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|PROSITE-
CC ProRule:PRU01360, ECO:0000305|PubMed:1317381}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU01360}.
CC -!- INDUCTION: Expression is up-regulated by low iron concentration
CC condition. Iron-regulated expression is repressed by Fur.
CC {ECO:0000269|PubMed:1317381}.
CC -!- DISRUPTION PHENOTYPE: Can not bind or utilize exogenous ferric
CC vibriobactin. {ECO:0000269|PubMed:1317381}.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; AF030977; AAB86828.1; -; Genomic_DNA.
DR EMBL; CP000627; ABQ21470.1; -; Genomic_DNA.
DR EMBL; CP001235; ACP10317.1; -; Genomic_DNA.
DR PIR; A41905; A41905.
DR RefSeq; WP_000279435.1; NZ_JAACZH010000022.1.
DR AlphaFoldDB; A5F661; -.
DR SMR; A5F661; -.
DR TCDB; 1.B.14.8.3; the outer membrane receptor (omr) family.
DR KEGG; vco:VC0395_A1803; -.
DR KEGG; vcr:VC395_2327; -.
DR PATRIC; fig|345073.21.peg.2243; -.
DR eggNOG; COG1629; Bacteria.
DR eggNOG; COG4774; Bacteria.
DR HOGENOM; CLU_008287_15_2_6; -.
DR OrthoDB; 127311at2; -.
DR Proteomes; UP000000249; Chromosome 2.
DR GO; GO:0009279; C:cell outer membrane; IC:UniProtKB.
DR GO; GO:0015092; F:high-affinity ferric iron transmembrane transporter activity; IMP:UniProtKB.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IMP:UniProtKB.
DR GO; GO:0015343; F:siderophore-iron transmembrane transporter activity; IMP:UniProtKB.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0034755; P:iron ion transmembrane transport; IMP:UniProtKB.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; IMP:UniProtKB.
DR Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR039426; TonB-dep_rcpt-like.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR NCBIfam; TIGR01783; TonB-siderophor; 1.
DR PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR PANTHER; PTHR30069:SF37; VIBRIOBACTIN RECEPTOR; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR SUPFAM; SSF56935; Porins; 1.
DR PROSITE; PS52016; TONB_DEPENDENT_REC_3; 1.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..37
FT /evidence="ECO:0000305"
FT CHAIN 38..687
FT /note="Ferric vibriobactin receptor ViuA"
FT /id="PRO_0000324813"
FT DOMAIN 62..184
FT /note="TBDR plug"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
FT DOMAIN 189..687
FT /note="TBDR beta-barrel"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
SQ SEQUENCE 687 AA; 76413 MW; 2CB4FA9BBAD1AF87 CRC64;
MAVLCPARVS VAENKKFKLH TLSAMMMGLF TGSFAYAETQ NTSNQEQEMP VLVVIGEKTQ
RSIYETSASV EVFDQDTIER TPGATEIDDL LQLIPNLVDS GQSNNMPTIR GIDGSGPSVG
GLASFAGTSP RLNMSIDGRS LTYSEIAFGP RSLWDMQQVE IYLGPQSYIQ GRNTSAGAIV
MKSNDPTHHF ESAVKAGIGE SDYSQTAGMI SAPIIQDELA FRLSFDQQKR DSFVDLAAFE
PAGDPKKIEM NSVRGKLLYE PSALDGFKTT LTLSHMDSRG PQTENINVAG NEAFRPVYET
ASFTTAWDII WHLNDLFTFE NNLVYADFSY DRYTNPNSRG DFNTDGKEFH IEPLLRYIAL
DGSVNTLIGA RYYQSSQDDM YIDAASAYPM DGRTKAKSVF AEVTYALTPS INVNLAGRFE
REQVKRNVSH PRYKLDYDET SSVFLPKLDV AYTPVQGQTY GIKAAKGYNA SGAGLAFNSM
QFTGFRPYEF EQESIWNYEF YTRHRFSHSV EVLTNLFYND FDSMQMTQTT SSGDVFIANL
DEASTYGAEI GSRWYATSSL ELFANLGLLK TEFKETTGNT KELPRAPKMS ANVGLLYDFG
QGFEFSSNAA YTGSYFSESG NSEKFAIDSY WVANAQLAYV FEHGRATLYA TNLLDSDKTT
LYLSTNNTLD QLKQQPRMIG ASVQLNF
//
