ID A5FBV0_FLAJ1 Unreviewed; 600 AA.
AC A5FBV0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2 {ECO:0000256|ARBA:ARBA00014657};
DE EC=2.3.1.179 {ECO:0000256|ARBA:ARBA00012356};
DE AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase II {ECO:0000256|ARBA:ARBA00032171};
DE AltName: Full=Beta-ketoacyl-ACP synthase II {ECO:0000256|ARBA:ARBA00029675};
GN OrderedLocusNames=Fjoh_4313 {ECO:0000313|EMBL:ABQ07321.1};
OS Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS 14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=376686 {ECO:0000313|EMBL:ABQ07321.1, ECO:0000313|Proteomes:UP000006694};
RN [1] {ECO:0000313|EMBL:ABQ07321.1, ECO:0000313|Proteomes:UP000006694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 /
RC UW101 {ECO:0000313|Proteomes:UP000006694};
RX PubMed=19717629; DOI=10.1128/AEM.01495-09;
RA McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA Cheng Y.Q., Stein J.L.;
RT "Novel features of the polysaccharide-digesting gliding bacterium
RT Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL Appl. Environ. Microbiol. 75:6864-6875(2009).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP000685; ABQ07321.1; -; Genomic_DNA.
DR AlphaFoldDB; A5FBV0; -.
DR STRING; 376686.Fjoh_4313; -.
DR KEGG; fjo:Fjoh_4313; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_10; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000006694; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR03150; fabF; 1.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50977; HTH_TETR_2; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..61
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DOMAIN 187..597
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DNA_BIND 24..43
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 600 AA; 65389 MW; A469F28893E546FE CRC64;
MTTRENIIDK ADQFIRNKGY NAFSFKDISN DIGIKTASIH YHFPTKSDLG VATIKEHIAR
YEVLKKKVAN ESPLIKLESF LAVHTQIKHE NKVCIVGSLA TDLNTLDESI KDELKIFAKL
VIDWLTEVLT EGKEQNIFDF QTSARTKALM IITNMVAIVQ LSRLTNDDDF ELVRETILTE
LRPKKIMKRV VVTGLGAVTP IGNNVQEYWN SLINGVSGAA PITRFDTTQF KTKFACEVKN
FDASPIFEKN EIRKYDLFTQ YALHAADEAV KNANIDFDTL NKNRIGVIWG CGDGGISTFE
EQFGEYKLGN GTPRFSPFFI PKRIVNIASG VISIKYGLRG INYTTAAACS ASNTAIIDAF
NYIRWGKADM IISGGSEASV SESSIGGFNA SKALSTLNED HSKASRPFDV TRDGFVLGEG
AGVVILESYE HAVKRNAVIL AEIVGGGLAA DAYHLTGTHP EGEGAVLGME LALEEAGITP
DKIDYINAHA TSTPAGDLSE LKAIEKVFGI NPNANISATK SMTGHLLGGA GAIEAVACIK
ALQENIVPPT INTQTIEQDY AEKFNLTLGK AQAREVNYAM SNTFGFGGHV ASSIFKKFKE
//
