ID MUTS_DEHMB Reviewed; 858 AA.
AC A5FQC0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=DehaBAV1_1029;
OS Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 /
OS BAV1).
OC Bacteria; Chloroflexota; Dehalococcoidia; Dehalococcoidales;
OC Dehalococcoidaceae; Dehalococcoides.
OX NCBI_TaxID=216389;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA Ritalahti K.M., Loeffler F., Richardson P.;
RT "Complete sequence of Dehalococcoides sp. BAV1.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000688; ABQ17609.1; -; Genomic_DNA.
DR AlphaFoldDB; A5FQC0; -.
DR SMR; A5FQC0; -.
DR KEGG; deb:DehaBAV1_1029; -.
DR PATRIC; fig|216389.18.peg.1084; -.
DR HOGENOM; CLU_002472_4_0_0; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..858
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000075554"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 858 AA; 95692 MW; B9B7C329E92939E4 CRC64;
MENTTPLRKQ YLDIKKNYPE AIVFFRLGDF YETFEEDARI AARELEIVLT SREMGKGLKV
PLAGIPYHAL DNYLSRLINK GYKVAICEQV TKPGETKGLV QRQVTRLVTP GTVVEPNLLQ
TKQNNFLLSL YLTEDSCGLA FADISTSEFG CTQTNIGELE AEISRLSPAE IILPKNQSLN
LPIHLKATIS KLDGYYFEAD IAREHLLRHF ECQNLSAYGC ENMPLAISAA GALLNYLEET
QKSSLKQLER LSVYTTADYM QMDSHTLSNL EIFRSSGGNS LKGSLLGILD QTRTAMGGRL
LRKFLGQPLL KQSDIEKRLS AVDYFFEESL ARTSLAKSLG QIADMERMAN RIRQKTILPR
ELISLKNSLE TVSAIHRQFG LMPPPRLAYF LNGLKPLPEM LDIINKTITD DPPSTLGDGK
VIRAGFDPEM DKLCSLAGDA RTFLSQMETR ERERTGIKSL KLGYNRVFGY YIEISNANLG
DMPPEFIRKQ TLVNAERFIT PELKEYENLI LNAKERLLEM ETGLYEQVLN QLGGFYSALL
ANAAALAALD VLSAFAEVAV RNSYVRPVFH PENRLDIRKG RHPMVEQGLG YGSFVANDIS
LSAEDCQIII LTGPNMAGKS TYLKQTALIV LMAQIGSYVP AETAELCLTD RIFTRIGARE
DLSAGQSTFM VEMVETASIL NTATSRSLLI LDEIGRGTST YDGLAIAQAV VEYIHSQPSL
TAKTLFATHY HELVELASYL PRVKNYNIAV SEDRGEVVFL HKIVPGGVDK SYGIHVAKLA
GLPKWVIKRA YEVLTELENP AKKQPKSRTC QPQLQLPMTG QTSVLEEEIK ELEIESLTPL
AALNKLYELK KKAEEQGL
//
