ID A5FUZ0_ACICJ Unreviewed; 579 AA.
AC A5FUZ0;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABQ29422.1};
GN OrderedLocusNames=Acry_0194 {ECO:0000313|EMBL:ABQ29422.1};
OS Acidiphilium cryptum (strain JF-5).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acidiphilium.
OX NCBI_TaxID=349163 {ECO:0000313|EMBL:ABQ29422.1, ECO:0000313|Proteomes:UP000000245};
RN [1] {ECO:0000313|EMBL:ABQ29422.1, ECO:0000313|Proteomes:UP000000245}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JF-5 {ECO:0000313|EMBL:ABQ29422.1,
RC ECO:0000313|Proteomes:UP000000245};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.;
RT "Complete sequence of chromosome of Acidiphilium cryptum JF-5.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. YfcE
CC family. {ECO:0000256|ARBA:ARBA00008950}.
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DR EMBL; CP000697; ABQ29422.1; -; Genomic_DNA.
DR RefSeq; WP_011941341.1; NC_009484.1.
DR AlphaFoldDB; A5FUZ0; -.
DR STRING; 349163.Acry_0194; -.
DR KEGG; acr:Acry_0194; -.
DR eggNOG; COG0535; Bacteria.
DR eggNOG; COG0639; Bacteria.
DR HOGENOM; CLU_526321_0_0_5; -.
DR Proteomes; UP000000245; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00838; MPP_superfamily; 1.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF12850; Metallophos_2; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000245};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 34..215
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF12850"
FT DOMAIN 304..443
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|Pfam:PF04055"
SQ SEQUENCE 579 AA; 61702 MW; 2DB59DE6254BEED2 CRC64;
MLDMAGSAPA IGPETVPVIE ADGPVLVFGG CYSNLQATRA LLEAARAHGI PPERMICTGD
VVAYGADPQA CAALIRDHGI ATVMGNCEEQ LGAGAADCGC GFTEGSSCDR LAAAWFAYAV
ARIDDATRRW MAALPRRIDL VIGGRRLAVV HGAPSRINRF LFASDPDLVL EREIGITGCD
GVIAGHCGIG FTRRIGDLVW HNAGAIGMPA NDGTPRCWYS IVTPTDAGLE IVLHPLDYDH
HAAAAAMRSA GLPEEYAGTL ESGIWPNLDI LPHAERAATA TRLECAPAAD ATVALEGLET
LWFNTGTLCN LACEGCYIES SPRNDRLAWL RLDGFRRVLD EAADRHPELR EIGLTGGEPF
MNPDIEALIG MALDRGYRVL VLTNAMTPMR HHMAAIAGWR GRDLHLRVSL DHHTEAGHAA
LRGERAWGPA LEGIGALFAS GFQPSIAARF DPAVEDEAAT RAGFARLFAA QGWEIDAFDP
EHLVLFPEMD VPAAAAGVSA SAWAALRPRG ADAMCRTSRM VVQRKGAEAL SIVACTLLPY
EARFDLGATL EDASRAVTLD HPHCARFCVF GASSCMSAR
//
