ID A5FYL3_ACICJ Unreviewed; 796 AA.
AC A5FYL3;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=MscS Mechanosensitive ion channel {ECO:0000313|EMBL:ABQ30695.1};
GN OrderedLocusNames=Acry_1487 {ECO:0000313|EMBL:ABQ30695.1};
OS Acidiphilium cryptum (strain JF-5).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acidiphilium.
OX NCBI_TaxID=349163 {ECO:0000313|EMBL:ABQ30695.1, ECO:0000313|Proteomes:UP000000245};
RN [1] {ECO:0000313|EMBL:ABQ30695.1, ECO:0000313|Proteomes:UP000000245}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JF-5 {ECO:0000313|EMBL:ABQ30695.1,
RC ECO:0000313|Proteomes:UP000000245};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.;
RT "Complete sequence of chromosome of Acidiphilium cryptum JF-5.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP000697; ABQ30695.1; -; Genomic_DNA.
DR AlphaFoldDB; A5FYL3; -.
DR STRING; 349163.Acry_1487; -.
DR KEGG; acr:Acry_1487; -.
DR eggNOG; COG0668; Bacteria.
DR HOGENOM; CLU_013626_0_0_5; -.
DR Proteomes; UP000000245; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000245};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..796
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002681851"
FT TRANSMEM 228..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 602..666
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 673..759
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 185..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 85395 MW; 0524CAE91B9BB384 CRC64;
MKRDAPFRGE MFRALSLALP ILALLLGAIP AASAAAPASK ATAAATSPAV KAAPPLTATQ
IDTAIATLRD AKQRATLIAT LEAMKGGATA ATTQQAAPGI GLGIAQTIEE WAEQTLQGIG
RALSDATDIS LIWHWIEFVA TDAWLRHTVL QATWRLAVVL VAALCAEWVV RRALRQPRTS
LLRNAARRRA ADGPGQEADG AEGIAAAEAG ETERSRRRQP LRRWLRRVPW ALGHFALELV
PVIAFALAGV ALVSGGIADD RVSRLVIGAA LEAYVVSRFA MECARLLLNP RAPEIRLAGL
GDDRARWLTT WLRAIVGTVA FGYAAIATGG LFGLYPAASR VLVKIVSLAV HLMLAVMILQ
ARRPVAAFIR GETPSAGFTG ALRVGLAHTW HILALFYVIA LWVAWAIGVP HAFFIMLRIV
VVLGLVAIIG RGVAASLASG LDSLFDERGT LRSRHPDLHA RMRTYLPVLK LSTGCVIAAL
GLLVTLQLWG VSVFAWFAGT TLGRQIASAV VTIAAAILIA LIVWEAANAA LEAHAERLIR
QGRPGRAARY RTLLPMLRSV LMGAILVVVA LVVLGAVGVN ITLLLGGLSI FGLAVGFGSQ
KLVQDIITGL FLLLEDAVQV GDWVTLAGIS GSVEKLSIRT IRLRAGDGSL NVIPFSAVST
VSNFSREFSF APITVGVAYK EDIDRVFAVI RDEFTKMRAD PEWAPNILGD IELWGLDQFG
ASSLDIVGRM RTPAGQQHAV RREFNRRLKI RFDTEGIEIP FPYQRLTIDP EEFRAAFGSG
TSGEARRPHE TTPENG
//
