ID A5G786_GEOUR Unreviewed; 395 AA.
AC A5G786;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ABQ27654.1};
GN OrderedLocusNames=Gura_3499 {ECO:0000313|EMBL:ABQ27654.1};
OS Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=351605 {ECO:0000313|EMBL:ABQ27654.1, ECO:0000313|Proteomes:UP000006695};
RN [1] {ECO:0000313|EMBL:ABQ27654.1, ECO:0000313|Proteomes:UP000006695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rf4 {ECO:0000313|EMBL:ABQ27654.1,
RC ECO:0000313|Proteomes:UP000006695};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA Lovley D., Richardson P.;
RT "Complete sequence of Geobacter uraniireducens Rf4.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000698; ABQ27654.1; -; Genomic_DNA.
DR AlphaFoldDB; A5G786; -.
DR STRING; 351605.Gura_3499; -.
DR KEGG; gur:Gura_3499; -.
DR HOGENOM; CLU_018816_2_1_7; -.
DR OrthoDB; 9772050at2; -.
DR Proteomes; UP000006695; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000006695};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..395
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002683296"
FT DOMAIN 43..363
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 66..296
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 395 AA; 41235 MW; 4220B32AE3AC8F8C CRC64;
MQNKCRTKLI IVAGLLVAGV MVTGCGKKTN AGGPPPSGPP EVGVVVVQPE SVSLTTELPG
RTSPQLIAEV RPQVGGIIQK RLFTEGSDVK AGQVLYQIDP ATYQAAFASA KAAEARAEAN
LVPARLKEGR FHDLVKIKAV SQQDYDDASA SLKLAEADLA SSRAAVETAR INLAYTKVTA
PISGRIGRST VTNGALVTAS QPAALATIQQ LDSMYVDVTQ SSADLLKLKQ NLASGLLKSG
GASQARVKLL LEDGSAYPLP GTLKFSEVTV DQSTGSVTLR AIFPNPKQTL LPGMFVRAIL
EEGVNENAIL VPQRGVTRNP QGEAMVMAIG AGEKVEPRPI KVVRTVGDNW LVSDGLKAGD
RVILEGLQKA KPGTPVKAVQ FAAKPAAPAA VAVNK
//
