ID A5GCG3_GEOUR Unreviewed; 501 AA.
AC A5GCG3;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABQ24731.1};
GN OrderedLocusNames=Gura_0516 {ECO:0000313|EMBL:ABQ24731.1};
OS Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=351605 {ECO:0000313|EMBL:ABQ24731.1, ECO:0000313|Proteomes:UP000006695};
RN [1] {ECO:0000313|EMBL:ABQ24731.1, ECO:0000313|Proteomes:UP000006695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rf4 {ECO:0000313|EMBL:ABQ24731.1,
RC ECO:0000313|Proteomes:UP000006695};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA Lovley D., Richardson P.;
RT "Complete sequence of Geobacter uraniireducens Rf4.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP000698; ABQ24731.1; -; Genomic_DNA.
DR RefSeq; WP_011937456.1; NC_009483.1.
DR AlphaFoldDB; A5GCG3; -.
DR STRING; 351605.Gura_0516; -.
DR KEGG; gur:Gura_0516; -.
DR HOGENOM; CLU_021572_4_0_7; -.
DR Proteomes; UP000006695; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF17; MG-PROTOPORPHYRIN IX MONOMETHYL ESTER OXIDATIVE CYCLASE 66KD SUBUNIT; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000006695}.
FT DOMAIN 12..146
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 191..416
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 501 AA; 56500 MW; 16A4465AF26B4A61 CRC64;
MNIKKVALIT PPYHSGVVES AGTWLNVGFV YIAGALRAAG YEVDYYDAMS LWHKWPEIQQ
RIEAFNPDVV ATTAYTASIV HAIELTRLAK KINPQVVTVH GNVHATFCYE EMLTAEHDTI
DFIVRGEGET TLPSLLDCLN AGGDPATVPG LAFYRDGAVV ATPKAPYIQD LDALPAAWDL
VEWPIYSYRA KNNARLAIVS SSRGCQQKCS FCSQQLFWAQ TWRARSADNF VAELEMLNKT
YGVEVAMLAD EIPTFDRERW VRILDLMIER QVPVKLLMET RVDDILRDAD IMDKYRQGGV
EHIYVGVEAG SQETLDLFKK DTKVEQSKQA IDIINNADIV SETSFVLGMP EDTPESIAAT
IELAKHYNPD MAFFLAIAPW PYAELYPQLE KYVATKDYRK YNLVEPVIKP IHMTVEDLER
ELGKAAQKFY MHKFQNLDKL TPWKREFMLA VFDILINNSY LAGQMRAMMK EGKEMPAEVK
ALIQNVKGHK GGIPHGIAPI P
//
