ID A5GFM7_PIG Unreviewed; 307 AA.
AC A5GFM7;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Natural cytotoxicity triggering receptor 1 {ECO:0000256|ARBA:ARBA00040484};
DE AltName: Full=Natural killer cell p46-related protein {ECO:0000256|ARBA:ARBA00041225};
GN Name=NCR1 {ECO:0000313|EMBL:CAN13349.1};
GN ORFNames=PigE-173F2.3-001 {ECO:0000313|EMBL:CAN13349.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:CAN13349.1};
RN [1] {ECO:0000313|EMBL:CAN13349.1}
RP NUCLEOTIDE SEQUENCE.
RA Phillimore B.;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000256|ARBA:ARBA00006531}.
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DR EMBL; CR853303; CAN13349.1; -; Genomic_DNA.
DR RefSeq; NP_001116615.1; NM_001123143.1.
DR AlphaFoldDB; A5GFM7; -.
DR SMR; A5GFM7; -.
DR GeneID; 100141419; -.
DR KEGG; ssc:100141419; -.
DR CTD; 9437; -.
DR OrthoDB; 5263025at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR PANTHER; PTHR11738:SF14; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CAN13349.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..307
FT /note="Natural cytotoxicity triggering receptor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030164754"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..190
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 283..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33909 MW; 80F06BFCEBA8AFE7 CRC64;
MPLAPAALLF LGLCLSQSTR TQQQTLSKPV IWAKPSFMIP KGHPAVIWCQ GPHQAVEYQL
LFEGGLSALG RPKSPGSVNR AKFSVQAMNS NTAGQYQCLY RSGERWSQPS DPLDLVVTGL
YDTPALSVQP RPEVTSGENV TFSCRLETAT SMFFLLKEGR SSRPQHGYGT MQAEFPMGPV
TRAHGGTYRC FGSYNKHAWS FPSEPVKLLV KGDGGDTTFA PTEHTSSPDG WDPYVLTVDT
PIQKEPDLWD HTGQNLLRMG IAFLVLVALV GLLIEDCLHR KRRQDRTHGA SSRGCRRRPR
AQSPLEK
//
