ID A5GHU2_SYNPW Unreviewed; 600 AA.
AC A5GHU2;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=aspartate kinase {ECO:0000256|ARBA:ARBA00013059};
DE EC=2.7.2.4 {ECO:0000256|ARBA:ARBA00013059};
GN Name=lysC {ECO:0000313|EMBL:CAK22507.1};
GN OrderedLocusNames=SynWH7803_0081 {ECO:0000313|EMBL:CAK22507.1};
OS Synechococcus sp. (strain WH7803).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=32051 {ECO:0000313|EMBL:CAK22507.1, ECO:0000313|Proteomes:UP000001566};
RN [1] {ECO:0000313|Proteomes:UP000001566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH7803 {ECO:0000313|Proteomes:UP000001566};
RG Genoscope;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000709};
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004766, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC pathway; L-homoserine from L-aspartate: step 1/3.
CC {ECO:0000256|ARBA:ARBA00004986, ECO:0000256|RuleBase:RU004249}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 1/5. {ECO:0000256|ARBA:ARBA00005139,
CC ECO:0000256|RuleBase:RU004249}.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
CC {ECO:0000256|ARBA:ARBA00010122}.
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DR EMBL; CT971583; CAK22507.1; -; Genomic_DNA.
DR AlphaFoldDB; A5GHU2; -.
DR STRING; 32051.SynWH7803_0081; -.
DR KEGG; syx:SynWH7803_0081; -.
DR eggNOG; COG0527; Bacteria.
DR HOGENOM; CLU_009116_3_2_3; -.
DR OrthoDB; 9799110at2; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR Proteomes; UP000001566; Chromosome.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR CDD; cd04923; ACT_AK-LysC-DapG-like_2; 1.
DR CDD; cd04913; ACT_AKii-LysC-BS-like_1; 2.
DR CDD; cd04936; ACT_AKii-LysC-BS-like_2; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR Gene3D; 3.30.2130.10; VC0802-like; 2.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR041740; AKii-LysC-BS.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR001341; Asp_kinase.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR NCBIfam; TIGR00657; asp_kinases; 1.
DR PANTHER; PTHR21499; ASPARTATE KINASE; 1.
DR PANTHER; PTHR21499:SF3; ASPARTOKINASE; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF13840; ACT_7; 2.
DR SUPFAM; SSF55021; ACT-like; 4.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
DR PROSITE; PS51671; ACT; 2.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAK22507.1};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001566};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAK22507.1}.
FT DOMAIN 275..357
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT DOMAIN 443..528
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 600 AA; 61797 MW; FD625E0596285A7A CRC64;
MALLVQKFGG TSVGSVERIQ AVARRIAACK EDGNDLVIVV SAMGHTTDEL TAKARAISSN
PPQREMDMLL ATGEQVSIAL LSMALHALGV PAISMTGAQV GIVTESAHGR ARILDVRTDR
LRSRLAEGQV VVVAGFQGTS QSSGGTAEIT TLGRGGSDTS AVALAAALGA DACEIYTDVP
GVLTTDPRKV ADAQLMPEVS CDEMLELASL GAAVLHPRAV EIARNYGVTM VVRSSWSEDA
GTTLTSRSAR PIGRDGLELG RPVDGAELVE GQAVLALSHV SDQPGVAAQL FESLSAGGVN
VDLIIQSTHE GNSNDITFTV AESELEKARG ICADQLQTLG GELVAEAGMS KLSISGAGIM
GRPGIAAGLF QTLSRVGINL RLIATSEVKV SCVVEASAGA KALQATQDAF ELESDLISLN
PLPSGEGDPE VRGIALDRDQ AQVSVRHVPD KPGTAGALCN ALADAGISLD GIVQSERQHA
DGSRDISFTL KRDDRAAADR ALSHLLAQWP GALLEDGPAI ARVSAVGAGM PATAGTAGRM
FRYLADAGVN IEMIATSEIR TSCVVAESDG IAALQAVHTG FELGGSTRHQ AQGTESPLES
//
