ID   A5GIQ6_SYNPW            Unreviewed;      1045 AA.
AC   A5GIQ6;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Multidrug efflux transporter, Hydrophobe/Amphiphile Efflux-1 (HAE1) family (2.A.6.2.), RND superfamily {ECO:0000313|EMBL:CAK22821.1};
GN   OrderedLocusNames=SynWH7803_0395 {ECO:0000313|EMBL:CAK22821.1};
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=32051 {ECO:0000313|EMBL:CAK22821.1, ECO:0000313|Proteomes:UP000001566};
RN   [1] {ECO:0000313|Proteomes:UP000001566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803 {ECO:0000313|Proteomes:UP000001566};
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CT971583; CAK22821.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5GIQ6; -.
DR   STRING; 32051.SynWH7803_0395; -.
DR   KEGG; syx:SynWH7803_0395; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_3; -.
DR   OrthoDB; 9791035at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001566};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        369..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        396..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..560
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        874..894
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        901..921
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        976..996
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1002..1028
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1045 AA;  111789 MW;  12AD9834ABCDD94D CRC64;
     MRSISQPFLR RPVFTIVCSL LVLLAGTVAL VGLGLEDLPQ LAPTRVSVSA TFPAASPEVV
     EQSVTAVLEK QLNGLEGLES MTSSSRQGGA SLSLRFQSGD PELNAIKVQN EVNLASRRLP
     QAVTRQGLNV NRSTDDLLLI LGFSAPPGLY EPIFIGGWLD QNLREALRAV PGVGDIRVFG
     SSELAFRLWL DPNRLEQFNL STNDVTAALA EQNVLAAVGS LGEAPAPAGQ LFSLPIDAEG
     RLRNRADFEA MVVKRTEAGG LVRLKDVGRV QLGQRSYGSS TLNLEGNSSV AVGIFQRDGA
     NALEVSGAVM EALKRLESSF PPSLSMQVIV DVAETVQANL DRTTGTLRDA VVLVLVVLVL
     FLGRWRLALI PGIAVPVALI GSLVVVRLSG SNLNSLILFG LVLATGIVVD DAIVVSEDIA
     GRIEDGAEPQ GAAEDAMAEL AGAVVATSLV LAAVFLPVLL IPGSIGRLYQ PIALAISGAI
     LFSTFNALTF TPMACARVLS SGSGRLPGPV KRISQRLRQG MRRLQSWYGQ ALALWLPRGR
     IVLGLILTGL MLTGIGLATI PTSFIPDEDQ GQVRGYFTLP EGASLERTEA VMERIRQVIA
     EEPLIRSGNF YAGRSFGQSG EDRGAFYLRL APLKERSGRE NSSEAVKKRL NKALQRQITD
     ARVIVTTPPT VRGFSSESGL QMQLLDRSGG QLSLQEFETQ AQRFIRAAQG SGRFQRVSTR
     FDASSPRWRL EIDRTQMAAL DLPVGPTLRD IGTAIGGRYI DDTFEGGQIR SIYVQLEGSD
     RSTPDDLTSL MVRNRSGELV SVANVARLKR DSGANSITHY NQNRSISIIA VPTDAVSSGQ
     AIDLLQALSD RTGGSNLALT FTGLAKEETR AESVSWVLFA LGLTVVYLLL AGLYESFLDP
     LIILLTVPMA LLGALIGLKL RGLTLDVYAQ MGLLVLVSLA AKNGILIVEF ANQRLEQGIP
     LFDAIEEAAI NRMRPILLTA VTSLAGFLPL LLASGSGSAS RISIGTVVFS GLLVSTLLSL
     FVIPAIYLQL KRWRGVGPAM PELDG
//