ID A5GKU6_SYNPW Unreviewed; 378 AA.
AC A5GKU6;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Cobalamin biosynthesis protein {ECO:0000313|EMBL:CAK23561.1};
GN Name=cobW {ECO:0000313|EMBL:CAK23561.1};
GN OrderedLocusNames=SynWH7803_1135 {ECO:0000313|EMBL:CAK23561.1};
OS Synechococcus sp. (strain WH7803).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=32051 {ECO:0000313|EMBL:CAK23561.1, ECO:0000313|Proteomes:UP000001566};
RN [1] {ECO:0000313|Proteomes:UP000001566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH7803 {ECO:0000313|Proteomes:UP000001566};
RG Genoscope;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CT971583; CAK23561.1; -; Genomic_DNA.
DR AlphaFoldDB; A5GKU6; -.
DR STRING; 32051.SynWH7803_1135; -.
DR KEGG; syx:SynWH7803_1135; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_1_0_3; -.
DR Proteomes; UP000001566; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001566}.
FT DOMAIN 281..378
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 231..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41393 MW; 92AB813EF32E8E87 CRC64;
MPLMAKRLPV TVITGFLGAG KTTVLRHLLT QSGQRLAVMV NEFGTVGLDG DLIRSCGFCP
EEEVEGRLVE LNNGCLCCTV QDDFLPTMET LLQRSDQLDG IVVETSGLAL PRPLLQALEW
PAIRRRVHVN GVVTVVDGEA LSGGSPVGDP EALERQRQED QSLDHLTAIE DLFEDQLEAA
DLVLISRSDC LQPSQLDSVL EGIQPRLRPG AGTLAISQGQ VDPALVLGLE SSESTHRAHQ
PDDAGDHDHD HGHHDHSHHD HSHHDHSHHD HGHHDHSHVE AISGQIRLEG SFDRSLLEQL
LPEFARTHHV IRLKGRVWLP GKTLPLQIQM VGPRLDSWFE AAPEQAWTPP SGAGLELVVI
GLEAGAAERL ETRLVANR
//
