ID A5H2Q7_LODEL Unreviewed; 565 AA.
AC A5H2Q7;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Poly A polymerase head domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LELG_05772 {ECO:0000313|EMBL:EDK47591.1};
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508 {ECO:0000313|EMBL:EDK47591.1, ECO:0000313|Proteomes:UP000001996};
RN [1] {ECO:0000313|EMBL:EDK47591.1, ECO:0000313|Proteomes:UP000001996}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 /
RC NRRL YB-4239 {ECO:0000313|Proteomes:UP000001996};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
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DR EMBL; DS236869; EDK47591.1; -; Genomic_DNA.
DR RefSeq; XP_001528831.1; XM_001528781.1.
DR AlphaFoldDB; A5H2Q7; -.
DR STRING; 379508.A5H2Q7; -.
DR KEGG; lel:LELG_05772; -.
DR VEuPathDB; FungiDB:LELG_05772; -.
DR eggNOG; KOG2159; Eukaryota.
DR HOGENOM; CLU_019592_2_1_1; -.
DR InParanoid; A5H2Q7; -.
DR OMA; CVSHIEV; -.
DR OrthoDB; 5402987at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001680; P:tRNA 3'-terminal CCA addition; IEA:UniProt.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR PANTHER; PTHR13734:SF5; CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13734; TRNA-NUCLEOTIDYLTRANSFERASE; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001996};
KW RNA-binding {ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953}.
FT DOMAIN 83..223
FT /note="Poly A polymerase head"
FT /evidence="ECO:0000259|Pfam:PF01743"
FT DOMAIN 250..309
FT /note="tRNA nucleotidyltransferase/poly(A) polymerase RNA
FT and SrmB- binding"
FT /evidence="ECO:0000259|Pfam:PF12627"
SQ SEQUENCE 565 AA; 65422 MW; B3BA74D747322432 CRC64;
MQLPLHHSYF CTSFSPSSCQ FFFPKLFARL MNRRLFCRTF TRLVHSSMKQ HTILLNDSEQ
KIRNLLVGYC DYYRNQGGKP LTLRITGGWV RDKLLCNESQ DIDIAIDHLL GVDFVNGLQN
YLIEQDPEMS MRHVHTIKMN PLKSKHLETC TTKLYDIDLD FVNLRSEEYT EESRVPVIEF
GTPKEDAMRR DATLNALFYN LNEQKIEDFT GKGLQDLQDG VLRTPLSPVK TFLDDPLRIL
RLIRFACKFD FKIEKKTLEA MMELHNQKAL STKISKERIE IELRKALVSK NPSYGLRLIY
HCNLVKSIFY VDGLGFDETA MKHSVKRIPH HLLAASAIYP YFEQQIHKST IHMLRALEIF
DDDSKFNFWL SMILHPYSTV PRVKNKDVYD QFLRVGLKCK KSDINKISAI NLVSRTTIDQ
FLEAPQSVKR SDLGLYLREF PDFASLNLLV QCFIDCIHNV HVRGSLLLPP PPSPTTADLS
LRNKKLINET IAKYDSLFSH INQLGLEDVH IMKPLLEGRT IAKELEKKPG PWMKPVTDEV
LKWQLDNPSG SAEECMMYIK SKVTL
//
