ID A5H649_BOVIN Unreviewed; 904 AA.
AC A5H649; F1MZZ6;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|EMBL:ABN71659.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ABN71659.1};
RN [1] {ECO:0000313|EMBL:ABN71659.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17442537; DOI=10.1016/j.ygeno.2007.02.008;
RA Cargill E.J., Womack J.E.;
RT "Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9.";
RL Genomics 89:745-755(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; EF076741; ABN71659.1; -; Genomic_DNA.
DR EMBL; EF076742; ABN71660.1; -; Genomic_DNA.
DR EMBL; EF076745; ABN71663.1; -; Genomic_DNA.
DR EMBL; EF076746; ABN71664.1; -; Genomic_DNA.
DR EMBL; EF076749; ABN71667.1; -; Genomic_DNA.
DR RefSeq; XP_005226014.1; XM_005225957.3.
DR RefSeq; XP_010818546.1; XM_010820244.2.
DR AlphaFoldDB; A5H649; -.
DR SMR; A5H649; -.
DR HOGENOM; CLU_006000_4_1_1; -.
DR TreeFam; TF325595; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 7.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABN71659.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014296970"
FT TRANSMEM 705..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 754..897
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 904 AA; 103789 MW; ED91BD73E8A779C0 CRC64;
MSRPLPYHIH FFSGLLTCWI LCTSSAHKCT VRHEVADCSH LKLTQIPDDL PTNITVLNLT
HNQLRRLPPA NFTRYSQLTI LDGGFNSISK LEPELCQSLP WLEILNLQHN EISQLSDKTF
IFCMNLTELH LMSNSIQKIK NDPFKNLKNL IKLDLSHNGL SSTKLGTQLQ LENLQELLLS
NNKISSLTPE EFDFLGNSSL KRLELSSNQI KEFSPGCFHT LGELSGLSLN NAKLSPSLTE
KLCLELSNTS IENLSLSSNQ LDTISHTTFD GLKQTNLTTL DLSRNSLRVM GNDSFAWLPH
LEYLSLEYNN IEHLSSRSFY GLSNLRRLDL RRSFTRQSIS LTSLPKIDDF SFQWLKCLEY
LNMDDNNFPG IKRNTFTGLV RLKFLSLSNS FSSLRTLTNE TFLSLAGCPL LLLNLTKNKI
SKIQSGAFSW LGHLEVLDLG LNEIGQELTG QEWRGLDNIV EIYLSYNKYL ELTTNSFTSV
PSLQRLMLRR VALKNVDCSP SPFRPLPNLV ILDLSNNNIA NINDELLKGL EKLEILDLQH
NNLARLWKHA NPGGPVQFLK GLFHLHILNL GSNGFDEIPV EAFKDLRELK SIDLGMNNLN
ILPQSVFDNQ VSLKSLSLQK NLITSVQKTV FGPAFRNLSY LDMRFNPFDC TCESIAWFVN
WINSTHTNIS ELSNHYLCNT PPQYHGYPVM LFDVSPCKDS APFELLFMIN INILLIFIFI
VLLIHFEGWR ISFYWNVSVH RVLGFKEIDR AEQFEYAAYI IHAYKDRDWV WKHFSPMEEE
DHTLRFCLEE RDFEAGVLEL EAIVNSIRRS RKIIFVVTQN LLKDPLCKRF KVHHAVQQAI
EQNLDSIILI FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERVNAFH HKLKVALGSR
NSAH
//
