ID IL7RA_CALJA Reviewed; 459 AA.
AC A5HJM1;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Interleukin-7 receptor subunit alpha;
DE Short=IL-7 receptor subunit alpha;
DE Short=IL-7R subunit alpha;
DE Short=IL-7R-alpha;
DE Short=IL-7RA;
DE AltName: CD_antigen=CD127;
DE Flags: Precursor;
GN Name=IL7R;
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Matsuzawa A., Kohu K., Suemizu H., Sasaki E., Yagita H., Suzuki D.,
RA Kametani Y., Habu S., Satake M.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for interleukin-7. Also acts as a receptor for
CC thymic stromal lymphopoietin (TSLP) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP
CC receptor is a heterodimer of CRLF2 and IL7R (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding. {ECO:0000250}.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation. {ECO:0000250}.
CC -!- PTM: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the
CC unglycosylated form. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
CC subfamily. {ECO:0000305}.
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DR EMBL; EF534213; ABQ09497.1; -; mRNA.
DR RefSeq; XP_002745108.1; XM_002745062.3.
DR AlphaFoldDB; A5HJM1; -.
DR SMR; A5HJM1; -.
DR STRING; 9483.ENSCJAP00000034071; -.
DR GlyCosmos; A5HJM1; 3 sites, No reported glycans.
DR Ensembl; ENSCJAT00000035995.5; ENSCJAP00000034071.2; ENSCJAG00000018379.5.
DR GeneID; 100397720; -.
DR KEGG; cjc:100397720; -.
DR CTD; 3575; -.
DR eggNOG; ENOG502S4WE; Eukaryota.
DR GeneTree; ENSGT00510000048500; -.
DR HOGENOM; CLU_045398_0_0_1; -.
DR InParanoid; A5HJM1; -.
DR OMA; QIHRVDD; -.
DR OrthoDB; 4143009at2759; -.
DR TreeFam; TF336573; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000018379; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:Ensembl.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; IEA:Ensembl.
DR GO; GO:0033089; P:positive regulation of T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.1870; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR040997; FN3_7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF27; INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF18447; FN3_7; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein;
KW Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..459
FT /note="Interleukin-7 receptor subunit alpha"
FT /id="PRO_0000369415"
FT TOPO_DOM 21..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 131..231
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 327..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 217..221
FT /note="WSXWS motif"
FT /evidence="ECO:0000250"
FT MOTIF 272..280
FT /note="Box 1 motif"
FT /evidence="ECO:0000250"
FT COMPBIAS 330..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 282
FT /note="Phosphothreonine; by PKC"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 42..57
FT /evidence="ECO:0000250"
FT DISULFID 74..82
FT /evidence="ECO:0000250"
FT DISULFID 108..118
FT /evidence="ECO:0000250"
SQ SEQUENCE 459 AA; 51456 MW; 37541A485D1D6583 CRC64;
MTILGTTFGV FFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE
DPDVNTTNLE FEICGALVEV RCLNFRKLQE IYLIETKKFL LIGNSNICVK AGEKSLTCKN
VNVATIVKPE APFDLSVIYR EGANDFLVTF NTSHLQKKYV KVLMHDVAYR HEKDENNWMH
VNLSSTKLTL LQRKLQPKAT YEIKVRSIPG DYFKGFWSEW SPSYYFRTPE INNHSGETNP
TLLTISILSV LSVVLLVILA CVLWKKRIKP IIWPSLPDHK KTLEHLCKKP SKNLIVSFNP
ESFLDCQIHR VDDIQARDEV EGFLQDTVPP QLEESETQRP GGDVQSPSWP SENVVTTPET
FGRDSPLRCL AGNVSAHDAP ILSSSRSLDC RESATNGPHV NQDLLLSLGT TNSTLPPSFP
PQSRILTLNP VAQGQPILTF LGSNKEEAYV TMSSFCQKR
//
