ID A5I3J4_CLOBH Unreviewed; 423 AA.
AC A5I3J4; A7G4Z8;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Cytosine permease {ECO:0000313|EMBL:CAL83612.1};
GN Name=codB {ECO:0000313|EMBL:CAL83612.1};
GN OrderedLocusNames=CBO2073 {ECO:0000313|EMBL:CAL83612.1};
OS Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441771 {ECO:0000313|EMBL:CAL83612.1, ECO:0000313|Proteomes:UP000001986};
RN [1] {ECO:0000313|EMBL:CAL83612.1, ECO:0000313|Proteomes:UP000001986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A [Sanger]
RC {ECO:0000313|Proteomes:UP000001986};
RX PubMed=17519437; DOI=10.1101/gr.6282807;
RA Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA White B., Whithead S., Parkhill J.;
RT "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT Hall A and comparative analysis of the clostridial genomes.";
RL Genome Res. 17:1082-1092(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM412317; CAL83612.1; -; Genomic_DNA.
DR RefSeq; WP_011986589.1; NC_009698.1.
DR RefSeq; YP_001254570.1; NC_009495.1.
DR RefSeq; YP_001387863.1; NC_009698.1.
DR AlphaFoldDB; A5I3J4; -.
DR GeneID; 5186328; -.
DR KEGG; cbh:CLC_2016; -.
DR KEGG; cbo:CBO2073; -.
DR PATRIC; fig|413999.7.peg.2041; -.
DR HOGENOM; CLU_035711_1_1_9; -.
DR Proteomes; UP000001986; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015209; F:cytosine transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11484; SLC-NCS1sbd_CobB-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR030191; CodB.
DR InterPro; IPR001248; Pur-cyt_permease.
DR PANTHER; PTHR30569:SF0; CYTOSINE PERMEASE; 1.
DR PANTHER; PTHR30569; CYTOSINE TRANSPORTER CODB; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001986};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 423 AA; 44967 MW; 4EDBBC3C81277BAD CRC64;
MSKKQHVDKD YSFESVKEKD KKGFISMFAV MLGFTFFSAS MLTGGNLGVA LSIKDFALAV
FLGNLILAIY TGALAYIGAD TGLSMHLLAR YSFGEKGAYL PSFLTSFTQI GWFGVGVAMF
AIPVSKITGI NIYLLVAVSG LLMTSTAYFG MKSLTILSVI AVPAITLLGC ASMFRAVNAI
GGASQLLNIA PKGKMGLVTA VTLCVGSFIS GGSTTPDFVR FAKNKKIAVT TTVVAFFIGN
SLMFLFGAIG AMATGYSDIS DVMISQGLII PAILALGLNI WTTNDNAIYT SGLGISNITK
IPKSKVVIFN GILGTIGALW LYNNFVSFLS LLGAMIPAVG GIIIADYFFV RKRKYESLKE
ANFKVINYKA IGACILGILA GKYLTVGIPS INSLIITGVI HIILEKAIKE KTQKNVQCDE
YAA
//
