ID A5JZH6_PLAVS Unreviewed; 720 AA.
AC A5JZH6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Translocation protein SEC63, putative {ECO:0000313|EMBL:EDL47387.1};
GN ORFNames=PVX_122755 {ECO:0000313|EMBL:EDL47387.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL47387.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL47387.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL47387.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL47387.1}.
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DR EMBL; AAKM01000001; EDL47387.1; -; Genomic_DNA.
DR RefSeq; XP_001617114.1; XM_001617064.1.
DR AlphaFoldDB; A5JZH6; -.
DR STRING; 126793.A5JZH6; -.
DR EnsemblProtists; EDL47387; EDL47387; PVX_122755.
DR GeneID; 5476423; -.
DR KEGG; pvx:PVX_122755; -.
DR VEuPathDB; PlasmoDB:PVX_122755; -.
DR InParanoid; A5JZH6; -.
DR OMA; LIPCTYI; -.
DR PhylomeDB; A5JZH6; -.
DR Proteomes; UP000008333; Chromosome 14.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR004179; Sec63-dom.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF02889; Sec63; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..194
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 600..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 82261 MW; 822DE5A3D43A6DF7 CRC64;
MSQFRDTFTK DSKKEPLLSY DDSAFIFFAG TVLICVLIPC TYIYIKSLFN KIFNNDSRNL
KRSKHNSVYR SCACALCKGK QERRNKSTTL WEKLGYRRII QFFLLVLFWG LLFILVQQML
STKPMQTFDP FEILEVHTGA TVGEIKKAYR LKSLKYHPDK NPNDTSAAAK FILITKAYQA
LTDEISKENY EKYGNPDGPG MMKVGIGLPK LLIDEKYQLL ILSIFFLIFL VFIPAIFIIY
YQRQKQYGPN GVKIETLQYL TYTINENSRA KAYPEMLAAT AESRDIEFRA EDEEYVKRMI
DELVEPKKRT FKVPVITKNY FLILAHMQRR YDLLSEEMKE DLEKILQFSL LITHSMIEIS
ILRDWFLTAQ AALTFRRCLI QAFDIRSSSL LQIPHFTESI IKHVHKGKFA VKDILDFVHQ
SHESRKGLSE MTDEQILDVK SFCNIVPDIK MTAEIVVEDE THIVKGDVAS IYIHIDRTNL
HENEAAGYIH APYFPQPKFE EWWIVATYKG DDRILKYVHV KNCEKRIEEK LQFMVDRVGN
LCVSIYILSD CYFGCDKKLD LPFRAYSQTE IKREIFVHPE DIELDNEPTL FQQMIGDIGR
RDDSDDEVEA RASGDPNKRN SSARGSTASA ARSNSQHNQA SNAGSGTNAN SSGGHNSSGG
HNNSGDQNNS NSNSNSNNNS NSNDGGAGGG EQPPPSQRTV SRDHENYVPD DDSNEDSDDG
//
