ID A5K0U8_PLAVS Unreviewed; 637 AA.
AC A5K0U8;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Aspartyl protease, putative {ECO:0000313|EMBL:EDL46945.1};
GN ORFNames=PVX_085030 {ECO:0000313|EMBL:EDL46945.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46945.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46945.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46945.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46945.1}.
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DR EMBL; AAKM01000002; EDL46945.1; -; Genomic_DNA.
DR RefSeq; XP_001616672.1; XM_001616622.1.
DR AlphaFoldDB; A5K0U8; -.
DR STRING; 126793.A5K0U8; -.
DR MEROPS; A01.A95; -.
DR EnsemblProtists; EDL46945; EDL46945; PVX_085030.
DR GeneID; 5475980; -.
DR KEGG; pvx:PVX_085030; -.
DR InParanoid; A5K0U8; -.
DR OMA; NIIPMVA; -.
DR Proteomes; UP000008333; Chromosome 13.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 3.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF28; PLASMEPSIN X; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000313|EMBL:EDL46945.1};
KW Protease {ECO:0000313|EMBL:EDL46945.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 174..614
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 27..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..489
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 192
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 504
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 205..210
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 637 AA; 73902 MW; 63BF87973365BAC0 CRC64;
MMAIPSKRKY LQYKIGKLNS ELLQNLPTKK LKKKKKKGSY SFFEGEDEDE GEEEQENEQD
EQQQKEEEGD PPSDATMDNH ISHHNKGTHY GGEDHHPDEF PNCVNSDCHM SNDASAEPDY
LGQFMNGSGE KARAQTQRSN WSNWNSWSGA FKKKEVSSTD QVTLPLQQLQ DSQYVGYIQI
GNPPQTIRPI FDTGSTNIWV VSTKCKDDTC LKVHRYNYKL SRSFRYYKPH TNLDIMFGTG
IIQGVIGVET FRIGPFKVFN QPFGLVKREK RSEAKSNVFE RINFEGIVGL AFPAMLSTGK
TTIYENLMNT YKFSHNEFSI YIGKDNKHSA LIFGGVERRF FEGDIYMFPV VREYYWEIQF
DGLYIDHQKF CCDSSSIVYD MRKKKKKWKV QRNSFARKYL KKKTDLRDMS RVWHHRREGA
EEDSEEEDPS GENLSGESLS GEDKHGERST GGEVNPYGAH PERRGKGAHR RRRRRHRWRR
HRSRVNRRGK DEKLKKNQNY LIFDSGTSFN SVPKSEIGYF FKVVPPKKCD DSNIDEVVAS
YPNLTYVINN MPFTLTPAQY LVRKSDMCKP AFMEIEVSPE YGHAYILGNA TFMRYYYTVY
RRGDGRKGSY VGIAKAVHAE DNEEYLTALQ RKMNPVG
//
