ID A5K3K0_PLAVS Unreviewed; 1903 AA.
AC A5K3K0;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 22-FEB-2023, entry version 64.
DE SubName: Full=Ferlin, putative {ECO:0000313|EMBL:EDL46104.1};
GN ORFNames=PVX_117685 {ECO:0000313|EMBL:EDL46104.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46104.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46104.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46104.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46104.1}.
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DR EMBL; AAKM01000004; EDL46104.1; -; Genomic_DNA.
DR RefSeq; XP_001615831.1; XM_001615781.1.
DR STRING; 126793.A5K3K0; -.
DR EnsemblProtists; EDL46104; EDL46104; PVX_117685.
DR GeneID; 5475129; -.
DR KEGG; pvx:PVX_117685; -.
DR VEuPathDB; PlasmoDB:PVX_117685; -.
DR InParanoid; A5K3K0; -.
DR OMA; RCYIYAC; -.
DR PhylomeDB; A5K3K0; -.
DR Proteomes; UP000008333; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037721; Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 5.
DR SMART; SM00239; C2; 4.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR PROSITE; PS50004; C2; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1875..1898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..110
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 180..300
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 646..770
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1422..1558
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1666..1796
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 502..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..563
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1903 AA; 218730 MW; 7A53449C69786C05 CRC64;
MKTISVGFTI YEAQNLEVED KTLLDPLVIV RCCNEEYITK KKKKKYNAVN WEESYIWDRL
TLSEIEWNVA KIEFEVQSAN TFWRNDIIGV ISFELKLIKN KKNHQIYGTY PILYKNGTEI
RGQLRLKVIV CDEKDYVVNG DIFNELTERN EKPTLYGGTS GYYGTGYEDE EDNQVYTDLT
KAVVEENPIM VRDTHCRNYY LYVNIHKIED IYIDVDRKKF RDLYVTCEFN GCHLKSSQGR
NCVNYTFNEC FKIPIATPIL EDSIIIKIWD WNFLSNDELL AIGVLSFNQV KNESLNPTWI
NLYGFHKKEM DFEKDTNQLV TSDFSISMEG NYYLGRICIS SYVERINSFD SMNIAMTQSC
LAFDDPLYIP VTLLCDVYLV TGVLANNIYV QLSCGPFRKR TDYVRANEGD IPPRGGRNVK
NARQITANGE ANFSNLFNFD DLLNLDNFFT KVTERQKIIE RGESTEFYFS PRKGKIENLK
FCVVRDERQQ WDVIINVFER GGHQGDAADG GDGANSADGG DSAGSGASGD SGGPNARSRL
TDRQKYILSK RKGRRHGGRH AARNDRRKPS PRERSPGGVE KNEAYNTDRR IAYYRLPLKN
VLQYNEKLSR CPIWIPLKNI PQNVQGENNC MYNIFQNGSI LLNLEKAYDV QLGINRRKNL
IPMNYELRCY IYACRNVVSH FNDSPNTFVH ISCSGKMKIT SLVLSNSNPV FLQCLKMNVK
ILTDYSVGLP TIPLIVVTLY EFYNNTFYFI GRCFCNYDIY LRDNQMKCSF AERGSKYNVV
DQVRPRWIKL KGSKHVRAMY PNNLWQHRGN DKRLMQEYMC EKQRELRKNS GRSGSNMGGS
GINLGRSSNN GGHQYAYPHN ELQRGERVGD ILLYFELVQE KDALKIPVYP MITEIKKCTL
SFFCMSLENL ILMQRKKQLQ LVSDKPSRTT ITHPVILLSI TSYSSYGKKN NEIVIRYEKT
LKSNTRIHLK NWRNSFDQQS FEMFCIENLS LDLPLDPIFD PILNIKVYNK KIKEKYFIGE
TNISLVPYLP WIKDLDQVLY YLQAHDDYSE TIDLENVDTA FNLYKNKNAA LVISAISLAD
CEHTLSLKEE VGGGEFADDD EQWRRLPLFR HEGESGGGQG GEQGDSYGGL YGGLYGDPYG
GSYGDPYGGS YGDPYGGTYA YPYADPYGGA YTNPYTAQQA QQAPPYGNPQ MLPSGPAQSG
SPNEDVVKNL YKNNMQNPAT YGVINYSRAI NAEQFPSQGD PLRSPLGIGN GMDKMNRPYG
RGYPYTQGKQ TISTTYKIKY ENEVFKLHDD GVPEVIKTSY SVKNYPYIKI LTSKFILNVY
IPPRFILYVE GDKINVGKYV KNVHRVSVDG VLESYLDDIL IPSLPLRRKL NWSANTLQHM
RASENKITKG GMHFACYEKF PFVEIVGGQI KCFTKIRYQN LESENIPLSL KDVTSQNAFR
NKFRGAKKIP LYLKIRVYVL RGIRIYGVNN SYMANPYLIF SLGEKTSNLR NSFKENTLNP
EFRCLWESEA IFPEDEILTV SVYSAEDNFD KQINDLYIGS TEINLFDRWT SKEWRGMMKK
NKVPIEYRPL YSDDLKARPG GGGTAKSNDR SYYTSTTMMG SLYEKGGNWN GIFSFLDFFT
YLVRPTSSYL WGGRNYRQEE STLDSHQEGK NNGILEMWVE IMDYEQSKKI PIHKMGTPKK
TDIEIRIIIW RCTMLALDEN LSRTFDLTVT AELDCVNYNG ANSTIQSTDV HYSCKNGNAV
FNWRVVYPRI SHPLNTCFLQ LAAYNNNNVG VSEFLGEVNL ELSKYINKAS QIANKLELDA
ELKLRKKKGT DSDNNYNGYL QVTVQFLPQT KANMKPVGLG REEPNRNPYL RTPDSGRDWN
DFVYSIGFND IYKPFWGWLK IFFICLLLIW VFIMSFVYPS LLM
//
