ID A5K3Q2_PLAVS Unreviewed; 549 AA.
AC A5K3Q2;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=PUA domain-containing protein {ECO:0000259|SMART:SM00359};
GN ORFNames=PVX_117950 {ECO:0000313|EMBL:EDL46156.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46156.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46156.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46156.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmI family.
CC {ECO:0000256|ARBA:ARBA00038091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46156.1}.
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DR EMBL; AAKM01000004; EDL46156.1; -; Genomic_DNA.
DR RefSeq; XP_001615883.1; XM_001615833.1.
DR AlphaFoldDB; A5K3Q2; -.
DR EnsemblProtists; EDL46156; EDL46156; PVX_117950.
DR GeneID; 5475181; -.
DR KEGG; pvx:PVX_117950; -.
DR VEuPathDB; PlasmoDB:PVX_117950; -.
DR InParanoid; A5K3Q2; -.
DR OMA; PCIVNIK; -.
DR PhylomeDB; A5K3Q2; -.
DR Proteomes; UP000008333; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11572; RlmI_M_like; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.30.750.80; RNA methyltransferase domain (HRMD) like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR041532; RlmI-like_PUA.
DR InterPro; IPR019614; SAM-dep_methyl-trfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42873:SF1; METHYLTRANS_SAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42873; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE; 1.
DR Pfam; PF10672; Methyltrans_SAM; 1.
DR Pfam; PF17785; PUA_3; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 45..131
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
SQ SEQUENCE 549 AA; 62031 MW; 4EC939082D17FA9A CRC64;
MVLLLPLARG FFSEFAKRKN GAILPKWLNN YHSQISYVDS PAKRPSLVVT ERCVKNVLNG
FPWLYSKDVK NADELTLYSP CIVNIKNEYD EQLGVGIYNK NSIIASRVLS TNVNDCINEE
FFTSRIEKAY KKRLDLFPND QFFRVVNAES DFLPGVIIDK FDKLLCVQIN ASGMDILLHS
ILNSIQQVLN PEVIILKNDS KIRKLEKLPL KKEVYKGIYN APIEVRENGL TFFVDVLKGQ
KTGWYYDQRF NRAMLIGYCK NRRVLDLFSY VGSFGITLAY YGAKEVTCVD SSYDAIQYGI
KAAHYNGVMD KTNFVHSCVK KFLNVCLHAQ VGFLPGAINK EEAHCGEHLE GSESGCPKLL
YQRNVRSSSL ISGHLDLPPD GDLTTLSSLE NNAHASAPPS AQGGEKLLSD VQNMFIYGKS
KVDTIDVEDV ENLLLKTNRD EFLRKKYDVI LVDPPALARN SYLLPSALKI YQKLLYISFR
IVRKPGYVFV SSCNKLVGYE ELLVCIRRSL HWSKCEGTII GEGRISADHP VHVSLPETRY
LTSVLLMVS
//
