ID A5K4P4_PLAVS Unreviewed; 547 AA.
AC A5K4P4;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Eukaryotic peptide chain release factor GTP-binding subunit {ECO:0000256|ARBA:ARBA00015765};
DE AltName: Full=ERF2 {ECO:0000256|ARBA:ARBA00030845};
DE AltName: Full=Polypeptide release factor 3 {ECO:0000256|ARBA:ARBA00029585};
DE AltName: Full=Translation release factor 3 {ECO:0000256|ARBA:ARBA00030210};
GN ORFNames=PVX_091785 {ECO:0000313|EMBL:EDL45622.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL45622.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL45622.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL45622.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL45622.1}.
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DR EMBL; AAKM01000005; EDL45622.1; -; Genomic_DNA.
DR RefSeq; XP_001615349.1; XM_001615299.1.
DR AlphaFoldDB; A5K4P4; -.
DR STRING; 126793.A5K4P4; -.
DR EnsemblProtists; EDL45622; EDL45622; PVX_091785.
DR GeneID; 5474645; -.
DR KEGG; pvx:PVX_091785; -.
DR VEuPathDB; PlasmoDB:PVX_091785; -.
DR InParanoid; A5K4P4; -.
DR OMA; GKMESGC; -.
DR PhylomeDB; A5K4P4; -.
DR Proteomes; UP000008333; Chromosome 9.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03704; eRF3_C_III; 1.
DR CDD; cd04089; eRF3_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF36; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EDL45622.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EDL45622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 109..343
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61279 MW; 9091F6E3164F4F26 CRC64;
MNNEPFSFNA NAPSYYPGMA YQGGGAPASQ EENDADNGSS CPGTDNTEDP AVTDVQEQLK
KMAISEEPPV EQDEEEEPPT DLEKKDQVED SQGEKAEQVK NNLIQVDPRH HLNIIFIGHV
DAGKSTACGN ILYILGYVDD RTIEKYEREA KEKNRESWFL AFIMDINEEE RQKGKTVEVG
RAHFETKDRR FTILDAPGHK NFIPNMISGA AQADIGVLII SARKGEFETG FERGGQTREH
TLLARTLGIN QLIVAINKMD DPTCNWSEAR YDEIQKKITP FIKSCGYNIN KDVYFVPISG
LTGQNLSEHV SDENSKIYDA RASWYDTSKP TLFQILNTLP PPPWDEKGPL RIPLLEGYKD
NGIIAVGKIE SGTLYGNNMS CTLMPNKLKV KVLNVCLEED EVPYAKPGEN VRVKLLGVEE
DQISKGFVLC DSVNLCSVVS EFIGRVAIVE LLEHKPIITA GYFCIFHAHT TCEEIQFVDM
LEVIDKKTKK KKIKPKFIKN DCIVTAHFLL SNPVCIEVYE KLPQLGRFTL RDQGKTIAIG
KILELKG
//
