ID A5K4P8_PLAVS Unreviewed; 1216 AA.
AC A5K4P8;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN ORFNames=PVX_091805 {ECO:0000313|EMBL:EDL45626.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL45626.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL45626.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL45626.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC {ECO:0000256|ARBA:ARBA00010171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL45626.1}.
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DR EMBL; AAKM01000005; EDL45626.1; -; Genomic_DNA.
DR RefSeq; XP_001615353.1; XM_001615303.1.
DR AlphaFoldDB; A5K4P8; -.
DR STRING; 126793.A5K4P8; -.
DR EnsemblProtists; EDL45626; EDL45626; PVX_091805.
DR GeneID; 5474649; -.
DR KEGG; pvx:PVX_091805; -.
DR VEuPathDB; PlasmoDB:PVX_091805; -.
DR InParanoid; A5K4P8; -.
DR OMA; RFWTSQP; -.
DR PhylomeDB; A5K4P8; -.
DR Proteomes; UP000008333; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027131; SMC5.
DR PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 84..283
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT DOMAIN 884..1129
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..424
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 746..794
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 977..1004
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1216 AA; 141285 MW; 968A4EA8AC9981BE CRC64;
MTSPSKRKLV KPEPLAGKKK ANARAGVKAE GRSAVSGGVT SGVVSTLGSS SLAERTNGAT
APRLPPPTGP PRYSRLKKGA IIEITVFNWM VFSGPVTLKA EEGINLIAAA NASGKSSLVC
ALVFGLGYNS SILSRNKELI NYIKKGEKKS FIEIKLKKDE RTNTTIKRIM NITQNKLESF
WFVNCKKVSH TEILELQKEF HLNLGNLITF MPQENVSKFS RLSPEELFEC TLMAIDKNLL
ERYHHLKKLI REKKEGEHNV QLLTHQVKEE EKLITDLEEK KGKFESLKKL LAKVRTYRVK
KSILAMNAKK KQLADVKAKM DSLVKEKNEH FETLRQYLSE VEKCHKVINH LSEQLAKEKK
KIKEATTRYV RINVQLDEIE AEILGEEKVM EDAVQHLHEN EEYIKNLDKR KKKIEEELHQ
IERFFRERGA QMGVPVGVPV GVQFGEDDPG GLEQSLQEEL QNLANANKQL LMRKYALQTE
HASLVEKLQK RQNYQNIQEE KFLNSIEFTL RERILNYKRD IKSIVRTHRL LSESALEDIR
KGYDLSKITS QNEMNGAIID ELSKRNIIYG PLCKYIKCIN PQFDYVLEFS LKKYFNSFLL
IEKENTPLLE SLYKNYKLSV ITMSRENHKL CHVTNEMRER GVECFLYELF ESPQIVKNGL
MNFIPINISF VVREGTFKNK TTKDITSFNN FMLEEIAKQT NEQVGSLLYF CEQNVHRYRI
STYNQNVFID SFSFVDRRCK ILYYISSEVK KDISNLERRR SECEGELLTL KSKMDEMDLQ
KKQKNDQLNN LILQKSEVNI RKKKKLLLLR ELKSVEENLN LYLKGEQLID EKKDKISKRI
NHLNGRKVQL CADFFDTLKG HKANDMEAFS LWRRLSQWKR YLSLVRTQNA ESERKHQTIK
SQIDLENTKH AALTHHIEEL ENLIKVQKGE LSKEETKSLN EIKLSLEEID SILQDCAIQQ
RIYNNLERNE ERYNVLVLSI ERHNENVKRK KEQLKNLGKE LETNGKQIQF VLSNWVNQID
ECILFLNHNL EKFISFINPE YGAKIELVKK NELFERCELY IKVKFKKTAP FLLLSVSHQS
GGERSLTTML YILSIQKLTK NGFYVLDELN QGLDHTNEKK IFELLSCLSN PSMYKQHFMH
HYDYRHIQID YQSKPQYFIL TPQIIRDIFF RDITVHYLFN GFGVLSGQFD EVEPAAGVEA
AGVAEAAAED LLGDDF
//
