ID A5K4S6_PLAVS Unreviewed; 801 AA.
AC A5K4S6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDL45654.1};
GN ORFNames=PVX_091945 {ECO:0000313|EMBL:EDL45654.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL45654.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL45654.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL45654.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL45654.1}.
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DR EMBL; AAKM01000005; EDL45654.1; -; Genomic_DNA.
DR RefSeq; XP_001615381.1; XM_001615331.1.
DR AlphaFoldDB; A5K4S6; -.
DR STRING; 126793.A5K4S6; -.
DR ESTHER; plavs-a5k4s6; Acidic_Lipase.
DR EnsemblProtists; EDL45654; EDL45654; PVX_091945.
DR GeneID; 5474677; -.
DR KEGG; pvx:PVX_091945; -.
DR VEuPathDB; PlasmoDB:PVX_091945; -.
DR InParanoid; A5K4S6; -.
DR OMA; NWTFEDM; -.
DR PhylomeDB; A5K4S6; -.
DR Proteomes; UP000008333; Chromosome 9.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 2.
PE 4: Predicted;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 116..170
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT DOMAIN 506..718
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 39..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 88892 MW; EE6CB6A94E1AB170 CRC64;
MSGYPLSNVS VGLGSMLPAC KEMRVNPVPS NLVYLNANAN NNNQVDHGGG DAQKKDRGSS
PPRSASRSSA NQSNSKNDAK DEKQALECTS YKIGKGKKKN NNLDSMEELL FKLTNGNFKA
EKHHVYTADG YRLNLYRIVS TNKKDNLQKK KEVFCLNHGL FESSISYTCK GYESLAFQIF
ANDYDVWISN NRGNAFTKYV GKDYALKKLK ERYSLQDLKD IGVEVTEEMA AQGSSSASGD
DEKKSTESAS SSDEEGCREK GKNNNLRKAG KADDNAANNS SGKKNSEGTK SSVEESKSVP
PCCGTPGAKP SIGDASPAEG GSKVGSNKAE KSSPCTSSSS DSEGPEDAPA NIDSRALSDI
FKRAKGSKGA DKNESIKKVY CGIGIPDEVD PSLSADDEST VNSEGEKQEE DELDEGDYNL
GYEIDGSPDP PGPFGDSSSC DSNMVCSFPY VPKDPENGEA AGEAAECAEG VEDGEEVEEL
VNLNKHSEED DVVELNVPEM DNWTFEDMGT KDLPAVIKYI KNKTQREQIV YVGFSQGSVQ
LLIGCCLNDY LNNSIKRTYL LSLPIILKNK DKLLKSVKML LIASRWYKAI IGSKEFIQKV
FPEKMSTSMI SSSADLFTRN FFKLYTENVD ENYKKIYFRH TPSGTTSKAN LKKWCSSLHD
GPVSEAIDKY AHKCSFPITL VYGIKDCLVD AERSIEYMKK KFTKNDLKII SEPEWSHIDP
VLADNRNVVL SCILEDLKGE EKETKQEEEK ETKQEEKETK QEEEKETKQE EKKQTKQEEK
KQTKQEEKKK QQEEKKKQLK K
//
