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Database: UniProt
Entry: A5K529_PLAVS
LinkDB: A5K529_PLAVS
Original site: A5K529_PLAVS 
ID   A5K529_PLAVS            Unreviewed;      1410 AA.
AC   A5K529;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   02-DEC-2020, entry version 74.
DE   RecName: Full=Subtilisin {ECO:0000256|ARBA:ARBA00023619};
DE            EC=3.4.21.62 {ECO:0000256|ARBA:ARBA00023619};
GN   ORFNames=PVX_092460 {ECO:0000313|EMBL:EDL45757.1};
OS   Plasmodium vivax (strain Salvador I).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=126793 {ECO:0000313|Proteomes:UP000008333};
RN   [1] {ECO:0000313|EMBL:EDL45757.1, ECO:0000313|Proteomes:UP000008333}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Salvador I {ECO:0000313|EMBL:EDL45757.1,
RC   ECO:0000313|Proteomes:UP000008333};
RX   PubMed=18843361; DOI=10.1038/nature07327;
RA   Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA   Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA   Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA   Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA   Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA   Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA   Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA   Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT   "Comparative genomics of the neglected human malaria parasite Plasmodium
RT   vivax.";
RL   Nature 455:757-763(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of proteins with broad specificity for peptide
CC         bonds, and a preference for a large uncharged residue in P1.
CC         Hydrolyzes peptide amides.; EC=3.4.21.62;
CC         Evidence={ECO:0000256|ARBA:ARBA00023529};
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDL45757.1}.
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DR   EMBL; AAKM01000005; EDL45757.1; -; Genomic_DNA.
DR   RefSeq; XP_001615484.1; XM_001615434.1.
DR   EnsemblProtists; EDL45757; EDL45757; PVX_092460.
DR   GeneID; 5474780; -.
DR   KEGG; pvx:PVX_092460; -.
DR   EuPathDB; PlasmoDB:PVX_092460; -.
DR   InParanoid; A5K529; -.
DR   OMA; EYSTWNL; -.
DR   Proteomes; UP000008333; Chromosome 9.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR040935; Pro_sub2.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF18513; Pro_sub2; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003355};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003355,
KW   ECO:0000313|EMBL:EDL45757.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW   ECO:0000256|RuleBase:RU003355}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1410
FT                   /note="Subtilisin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002685102"
FT   TRANSMEM        1271..1294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          648..734
FT                   /note="Pro_sub2"
FT                   /evidence="ECO:0000259|Pfam:PF18513"
FT   DOMAIN          880..1130
FT                   /note="Peptidase_S8"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   REGION          80..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          573..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          753..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1388..1410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          715..735
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        86..102
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..169
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..276
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..334
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..380
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..506
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..619
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..801
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1389..1410
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1410 AA;  158757 MW;  6189A536895AD3B3 CRC64;
     MLSSLYVLPL ILVNILFQND WHRKKILSEL GNYNVKLVKR SRVLSNRTTG RINFLDEIKE
     SYKPLFDVYE LSAEFEKLRN AKGKGEEKRG RKKKKKKKKK KNDHIGGGDD KETPRLNLIK
     LSATQPDGGE HTQKGKSTEA PIREAHSGKS TGINKRAANF IQMLNDGNSN GRGDAEMGVE
     NEPDTFSKLI NEGNIEDFDH LEKDEPEGEE EKKQEEAGEA EAGAAEGKEK GEEAERKEEQ
     EEAKQPQEQE QRDHKSMREE ESQSASREEE RQSNMRESPP GGESPQEGGD NIEGGTEVAA
     RKGGDKSKGQ EREGEKNLMA SKKEGVKAEK PSEEGSPSGH SLQGEGAEEA PAASPAEDSD
     EKKEEEEEEE EEEEEEDSND QGREYQLNDG NSVAQEDIIT QEFDHYTIVT NSNDVLNDIR
     VDASDISKLS IESINIPYSE ANKTSFTHQR HIVLTNKGNK KYRVVLMTKN PKFIELEDEP
     DEKAENNTFI ERESMEQKRT PNGRGEHTSD RTNLYGGKGT LDFSKVYSGN GRGSGREVEN
     PHVETHTGGG TGEGGIRATI NRLFSFLTFG GNPGESARGA GESKDGGGKK ESANGGGDRH
     HHHYRHDLQS RDNRRSRHDR TKDLNEILSA DKLVDQYLLN LKNNTPERQE LIFVLRGDLD
     LHSTYMRRVI KRSNAKFEEH IKKNFQQVDS IVYDVSSPIN FLCFFVPTVF DMSNFHMLKE
     ALLVLQKELE RYMENWSFSN TYVTLDAPHV GGEGGASAGA GHDGRKDAHM GSRAGDQADG
     HADDRETGHT DHREGGAPHG KPRKFVKKKK NLYNVKYSFL RKFWSFDSII AFARKMNKKN
     MDIEKEILNF LPKELREYST WNLSVIRVFN AWFLAGYGNK NVKVCIIDSG VDKNHIDLMK
     NVYIPEYSEQ YEMTQDFYDF MVKNPTDSSG HGTHVTGIVG GLANDLGMVG VAPNVTLISL
     RFIDGVKYGG SFHAIKAINV CILNKAPIIN ASWGSSKYDA NIYLAVQRLK YTFNGKGTVL
     VTAAGNENKN NDEHPLYPSS FKLPHVYSVA SISKNFEISP FSNYGVNSVH IMAPGHHIYS
     TTPNNSYKIN TGTSMAAPHV CGVNALIYSV CYNQGFIPPA EEVLDILTRT SIKVISRRRR
     TINDSLVNAE AAVLTTLLGG LWMQMDCHFV KFNLEGGKEK HIPVVFSAYK KGIYETDIVI
     AVIPTEENSK VYGEILIPIR IVTDPKAENF KESPRNGKKM IIDENEASHD EVLSYICENA
     LYNLYEMDSN FLVMSLVLFF VAFILIVVGT IVFIKRKRHS KYCDDEDHDH NMMRNSVFEH
     HHILSGNTNH ALKMAKRSHV EKIRNSVRFS VVMGTQNNCV FKERAPKKLD FENYGDLIKK
     PLLKSPPKKF VNHRAEQNWG HEAEKKDPRD
//
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