ID A5K775_PLAVS Unreviewed; 1539 AA.
AC A5K775;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Regulator of nonsense transcripts, putative {ECO:0000313|EMBL:EDL44634.1};
GN ORFNames=PVX_094465 {ECO:0000313|EMBL:EDL44634.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL44634.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL44634.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL44634.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL44634.1}.
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DR EMBL; AAKM01000008; EDL44634.1; -; Genomic_DNA.
DR RefSeq; XP_001614361.1; XM_001614311.1.
DR STRING; 126793.A5K775; -.
DR EnsemblProtists; EDL44634; EDL44634; PVX_094465.
DR GeneID; 5473650; -.
DR KEGG; pvx:PVX_094465; -.
DR VEuPathDB; PlasmoDB:PVX_094465; -.
DR InParanoid; A5K775; -.
DR OMA; VCKKAAN; -.
DR PhylomeDB; A5K775; -.
DR Proteomes; UP000008333; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 262..602
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 40..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..302
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 284..312
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 330..360
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 372..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 912..939
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 94..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1539 AA; 172481 MW; 15DEA73E2F0F4FD2 CRC64;
MENTFDYNQI DVDDFDDFYN FCTLKGKKKN GKKIAEQFFQ TGGESGADVV DGGEGGEDGT
DNSSVDTTTV YKEGSKKSRP TGKKSKPARR TRNASHEKRL DDVQGEEEDH LMGRRALELD
HRYGYVDDGL HESGGDIALE DESLAEERIA KYGKTDAWNN LGCKKKKKKN QQRDTQNMGF
NNPHSNHNEK GHSLQERSSC GDRTSNRYVS LPREDYEQDK KKMYEDYNAR GKYPRECSQY
SNSNCDSYSY SVDMACASKG NKEKPKYFRC RYCEMDSVDS VVQCNTCNRW FCNGSYGTCG
SHIVTHLVRS KHKEIKLHKK SLLGETILEC YNCGCKNVFL LGFLPTPEEG VVVIICRDPC
LARCISLSGR GEAEQERVTQ EGGKQTDGQP ADGPQADGPQ AYGQQADAPQ TDGPQANGKG
HPAELKDPPE REPKEKKKGL PYEHFHGEDD PISTDEDDVA STKEDTNMVK NKGYLSSDDF
GYTSEQEKGS SAGGSSLNRF AAKKGQNGKE KTEQTEQTEQ TEQDVKSKDS EDASNYCATV
GNNLKELIKM KDWDLNKWQP VIEDRCLLDW LVNIPTAEEA ERKGKRTTSY NVNKLEELWK
NKKDVYIDEL DGEILNDEPV KVELRYEDAY HYQSIFAPLI QLEADYDKSI KEGQKQANVT
VRWDIGLNKK RYAHFIYVKE ESELRLVAGD ELKLSYTYPN GTVWSCEGHI SRIHNTEEIA
LELRTSSTAN GPWVNNITTG YAVEFVWKST AYDRMQLALN EFAQNSYSLS GYLYHKLLGH
EVSEESLNYY KTALSSQVHG KRSPPRIVNY SAPNLAALNH SQIDAIKKSL VSPLSLIQGP
PGTGKTLTCA TLVYHLSKTK MGKVLVTAPS NVAVDQLSVR IHKTGLKVVR LCAKSREYVP
SIADYLYLHN QMKLLKSDIG EELNKLLELK EEVGELSQKD ERRLKKLIFF AEYKILLEAD
VICTTCVGAM DKRLKRFRFS QVLVDEATQS TEPECLVPLV TGAKQIVLVG DHCQLGPIIV
CKKAANAGLG KSLFERLVML GITPFRLEVQ YRMHPALSEF PSYVFYDGCL QNGITLKERE
YPLKDFPWPN PKCPMFFYNS TGLEEMSASG TSYLNRAEAS NMEKLVRTLI SCGLKPTQIG
VITPYEGQRA YITSLFQKNI SYQHSTEIEV ASVDAFQGRE KDFILLSCVR SNKKLGIGFL
NDPRRLNVAL TRAKYGLIIC GNAKVLSRHH VMIKKMHNSN ETITNVNSVW INLLSQFKKK
ELIVEGCLSN LKPMNIHIPT PMKQPSRYIN FSYFLPSERP PRAGAFPGRG SGRSGRSGRS
GRSGRSGGSD SSGGSGESDG SLPGSGDGKT QSSNTFMHMN TSNLSYCSDA VMNKEFLSYM
HQRQVGGAKQ GVKSYVNNLS QLSQFNEDSI VNKNSPSDSF PNYEPAPSLS HSTKSYANPN
FLCYSNSGLS EDRNHVANHL VDSSFRENFG GGSFVRNSDL FPYQFYYGND RDASSLHNGQ
GSHGSHHTRK PRIAGGHHGE IKQKLANTAD VRRYRNRNV
//
