ID A5K7F0_PLAVS Unreviewed; 593 AA.
AC A5K7F0;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Phosphoglucomutase, putative {ECO:0000313|EMBL:EDL44709.1};
GN ORFNames=PVX_094845 {ECO:0000313|EMBL:EDL44709.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL44709.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL44709.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL44709.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL44709.1}.
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DR EMBL; AAKM01000008; EDL44709.1; -; Genomic_DNA.
DR RefSeq; XP_001614436.1; XM_001614386.1.
DR AlphaFoldDB; A5K7F0; -.
DR STRING; 126793.A5K7F0; -.
DR EnsemblProtists; EDL44709; EDL44709; PVX_094845.
DR GeneID; 5473725; -.
DR KEGG; pvx:PVX_094845; -.
DR VEuPathDB; PlasmoDB:PVX_094845; -.
DR InParanoid; A5K7F0; -.
DR OMA; GYCVDPE; -.
DR PhylomeDB; A5K7F0; -.
DR Proteomes; UP000008333; Chromosome 8.
DR GO; GO:0016868; F:intramolecular phosphotransferase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05799; PGM2; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR016066; A-D-PHexomutase_CS.
DR PANTHER; PTHR45745:SF1; PHOSPHOGLUCOMUTASE 2A-RELATED; 1.
DR PANTHER; PTHR45745; PHOSPHOMANNOMUTASE 45A; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
DR PROSITE; PS00710; PGM_PMM; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|RuleBase:RU004326};
KW Metal-binding {ECO:0000256|RuleBase:RU004326};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 49..188
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 222..326
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 337..456
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
SQ SEQUENCE 593 AA; 67483 MW; FD59EE0F5BEAEE72 CRC64;
MGQIQNEQLA VSVELWNLFR KPQYLADETK EALSTYDEEE LKRLFLRRLN FGTAGLRGKM
GVGFNAMNVV TIMQTTQGLC TYLINTYGIS LCKNRGIIFG FDGRYHSESF AHVAASVCLS
KGFRVYLFGQ TVATPILCYS SFKKSCLCGV MVTASHNPKL DNGYKVYAAN GAQIIPPVDV
NISDCILSNL KPWSEVYDYL NEDFYLKDTS LVEDIYYEMY DSFMSDMKSE FNFNCHRNSR
TKLVIVYSPM HGIGRKFVQG VMHIVGYNNL LTVPQQALPD ADFSTVTFPN PEEKGALNMS
MQLADVVNSP IVVANDPDAD RFACAEKFNN KWKIFSGDEL GIIFAYHLMK QNEKKNIDKS
KHVFICTVVC SRMLKKLCEM YGYKYDETLT GFKWLINKAI DLSQENYTTL YCYEEALGHA
LTKYVRDKCG ISALAYWIEV AVYLYENGLT FHEYLENIRK EIGYFVSNNG YYTVLDPTDV
VSIFNDFRGN GSYRSELGSY KVVHVRDLTT GYDSTTPDGK SLIAPTPDSQ SITLHFENTA
ILTVRASGTE PKVKWYSEIS RGSYESAKEE IDRLVDEVMP LFMQPDRYNV KRC
//
