ID A5K877_PLAVS Unreviewed; 812 AA.
AC A5K877;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Aminomethyl transferase, putative {ECO:0000313|EMBL:EDL44491.1};
GN ORFNames=PVX_083095 {ECO:0000313|EMBL:EDL44491.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL44491.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL44491.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL44491.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL44491.1}.
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DR EMBL; AAKM01000009; EDL44491.1; -; Genomic_DNA.
DR RefSeq; XP_001614218.1; XM_001614168.1.
DR AlphaFoldDB; A5K877; -.
DR STRING; 126793.A5K877; -.
DR EnsemblProtists; EDL44491; EDL44491; PVX_083095.
DR GeneID; 5473503; -.
DR KEGG; pvx:PVX_083095; -.
DR VEuPathDB; PlasmoDB:PVX_083095; -.
DR InParanoid; A5K877; -.
DR OMA; GWINNPL; -.
DR PhylomeDB; A5K877; -.
DR Proteomes; UP000008333; Chromosome 12.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01571; GCV_T; 2.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Transferase {ECO:0000313|EMBL:EDL44491.1}.
FT DOMAIN 374..526
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 606..683
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 732..782
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 812 AA; 93189 MW; 28711F3405DC65ED CRC64;
MNKQFSHLLN GIICRQKIVS PVRIVANSLD GSPKWMCKSG GRTFGTYGAV TRRRQKQREK
FYEEKYRHNP NHVPKFSKVK KGSWGGWINN PLKQVTKNNG SNFMYEQKVE EEISTEERDC
INRLIQMRKE ATKLGQTPPY RGGKNGEGRH EVIPPSVNLF SICDNFIDRR KEIINKIENP
QHFVDTHIKK LTEGYTNINQ LHESCNENGY AKAPGYLKDV LRKRRNTSGG ALWGNYKVVR
DEACTDREGA TNRVEVPQKG ASPSEVAPVP MEEPAMYSGI RKEDQQSNRV EGEEAKLGRE
MGPLLEYNLT KCTSETAEQG ALPIGDEQIL KKLYIEDILN YADEGEEIDI SCLDVFTTLS
TSDRNRKLGS LFSSHGASFI LYNNCIIPSK FSRGTLQEYF HTRNACSLFD KSYQLIVKFT
GRDSIYICNQ FLSSDLNDMK SNDVCYTCVL DNKAYILDTA YVLKGENEVV LISSGYYKKG
LYEFLSDYIL FCRDSGMDVH IQVETNKRVL SLQGPLSNLI LNDVLDYFNW GEATQGEKGV
KFLKNVIKED TEKCQPYGLY FQREENEKDK FVNIPYMSFK KLSMVKYAKE VANVRGEVSP
PHDEMNRYEI LCIRCGDTGE DGFEFVVDNN ISDHYVELFL SHVKVKLAGA YALNMLRMEA
GIPLYGIDIF KNTTPITASL AWTLKYKKIK ERNIFGYQNL LKEFSIKSKF RRIGIISNEL
IFKTCKILSY PYKEPIGYVT SCTWSPVYEK RIAQGYIKRE FAKNNEKVLI SIPTDIPQEF
SKKKKYKILR SRSAHRFTLA QVCAFPFVGH KY
//
