ID A5K9J3_PLAVS Unreviewed; 1366 AA.
AC A5K9J3;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Translation initiation factor IF-2, chloroplastic {ECO:0000256|ARBA:ARBA00044105};
GN ORFNames=PVX_080420 {ECO:0000313|EMBL:EDL44065.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL44065.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL44065.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL44065.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL44065.1}.
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DR EMBL; AAKM01000011; EDL44065.1; -; Genomic_DNA.
DR RefSeq; XP_001613792.1; XM_001613742.1.
DR STRING; 126793.A5K9J3; -.
DR EnsemblProtists; EDL44065; EDL44065; PVX_080420.
DR GeneID; 5473064; -.
DR KEGG; pvx:PVX_080420; -.
DR VEuPathDB; PlasmoDB:PVX_080420; -.
DR InParanoid; A5K9J3; -.
DR OMA; VQDMDVQ; -.
DR PhylomeDB; A5K9J3; -.
DR Proteomes; UP000008333; Chromosome 10.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1366
FT /note="Translation initiation factor IF-2, chloroplastic"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002685201"
FT DOMAIN 766..935
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 158..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 151434 MW; EE1952F15400C2ED CRC64;
MFGGWLLAPT TLLIVLYSSL RAKPNCCYAY KLPTGRVSSS PFNPCVQLRQ RKGSLVRGNF
CGRDDIVAAK RTASISDGDV LGGVDPLGSP PRWSRPSGWN AAGSLSQRVA LTQAKWQKGN
INRGNESKKK STRLFLLRSE HSGFPPIGRN AWGGNAPICA RPPKRSERNV TEEGNHGEDE
GGGNSEIITN VEAVPPNGGN NKKRKYAKVR EEKKKGNLPN VEGERFTGVA TALEEKEVKR
VKGVTNFGSN SISGETNASV RRSSNPRRGN QRSRDEPLYT TDRGNTHSAS HGQAAPPSLY
QRRGSEKEEK YKESHRESCK TNAYRYPPQL RTPEGDAPSE EDVGKTLEGE VYSVSPNAVL
VKIKNTNHFG MLFKRRCNFG DDVGDLNEYF QVKQKICVKT LGINMKKKLF YLGNVIRYNP
DVKLKEGDTS KGLITKLCES YLFVKVLKNG STGYLHRSKL FRPWERQNEG QQKGERQKGE
QQLGRHNHRW SSLLKMAQFT QLFNIWDIID VEIYERPDAN FKSNYILTIP EGSKTFGKLL
AYFDSLSGGD PFAHKGGDDR FAHKGGEGPL LTQGGNTPVE DPSDGEAGDR RKRRSRASPS
REGEHHEDST RDEQRTPPRG YPFSKKNKET LHKERASTKM YRVPENATLS VFAKMTKISP
SALKKFFIIN ESREYQSGHV LSADQMRKAS DHFGVSCVVD VGGGGGQLGG AQLEVVTPGE
EPTGESSRGE EAPPNGGTKL VLHTNRVESD PHIACPTENP REKSKKRNMV VTFIGHINHG
KTSLFDYICK TKEREKEKGL ITQNIRAFKV NSQSNDFSFT LIDTPGHEAF MPIRTRGVNI
SDLSILVISG EEGIQEQTVE CIKLIKEHHI RVVIAVTKVD LPNVSVDRIV NDLVYYEIYT
EMNGGDVQVV PCSIFNEKSV DKLVDAIFLE SAFLESAVLE SAVLESAVLE SAVLEPPFLE
PTSLEAPSGE GQTGGGVILD SFVDKNGIVS INLVQSGTLR VNDHFYAGSS YGKVKIMKDH
LNKKVKVARA SDPVMVIGYE KNSVPVAGDK FFVVQNEAVA EEIAKHHKNE LLTLQMRGFS
YGQEEGGLDR YREYIIREGA AIPEEERKQN GGDNPQEGQQ EGRQEERQEE RQVEDAPGKA
SLGEAAPREA APVREKDPKT VYVNYFVKCD KQGTIEVLKN CLQRLEAKDT LHRVKNKIVF
SSIGDITASD ITYAQSFNAI IIGFNVKLSK SCPKNAKHLL SAAKASCRFI YANVLYDLIS
QVEGVMKEKL SSKPRGTYKG QATILKVFNV SKLGKVAGCV VNSGTVNNHS NVRILRNDRV
IHIGKIVSLK IAKEEKEQVR QGDECGMGFE DFVDFLPGDA VESYQE
//
