ID A5PLA3_DANRE Unreviewed; 268 AA.
AC A5PLA3; D2J4Z6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=Insulin-like growth factor-binding protein 5 {ECO:0000256|ARBA:ARBA00013665};
GN Name=igfbp5a {ECO:0000313|EMBL:ACZ95800.1,
GN ECO:0000313|Ensembl:ENSDARP00000057368,
GN ECO:0000313|RefSeq:NP_001092224.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070620-8};
GN Synonyms=igfbp5b {ECO:0000313|EMBL:AAI42808.1,
GN ECO:0000313|RefSeq:NP_001092224.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ACZ95800.1};
RN [1] {ECO:0000313|EMBL:AAI42808.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larvae {ECO:0000313|EMBL:AAI42808.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18803835;
RA Sundstrom G., Larsson T.A., Larhammar D.;
RT "Phylogenetic and chromosomal analyses of multiple gene families syntenic
RT with vertebrate Hox clusters.";
RL BMC Evol. Biol. 8:254-254(2008).
RN [3] {ECO:0000313|EMBL:ACZ95800.1}
RP NUCLEOTIDE SEQUENCE.
RA Dai W., Kamei H.K., Zhao Y., Ding J., Du Z., Duan C.;
RT "Identification and characterization of the duplicated zebrafish IGFBP-5
RT genes.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20081093;
RA Dai W., Kamei H., Zhao Y., Ding J., Du Z., Duan C.;
RT "Duplicated zebrafish insulin-like growth factor binding protein-5 genes
RT with split functional domains: evidence for evolutionarily conserved IGF
RT binding, nuclear localization, and transactivation activity.";
RL FASEB J. 24:2020-2029(2010).
RN [5] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21505050;
RA Daza D.O., Sundstrom G., Bergqvist C.A., Duan C., Larhammar D.;
RT "Evolution of the insulin-like growth factor binding protein (IGFBP)
RT family.";
RL Endocrinology 152:2278-2289(2011).
RN [6] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21653807;
RA Amaral I.P., Johnston I.A.;
RT "Insulin-like growth factor (IGF) signalling and genome-wide
RT transcriptional regulation in fast muscle of zebrafish following a single-
RT satiating meal.";
RL J. Exp. Biol. 214:2125-2139(2011).
RN [7] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22899520;
RA Amaral I.P., Johnston I.A.;
RT "Experimental selection for body size at age modifies early life-history
RT traits and muscle gene expression in adult zebrafish.";
RL J. Exp. Biol. 215:3895-3904(2012).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000057368}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000057368};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [9] {ECO:0000313|Ensembl:ENSDARP00000057368, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000057368};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [10] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28772162;
RA Liu Y., Wu D., Xu Q., Yu L., Liu C., Wang J.;
RT "Acute exposure to tris (2-butoxyethyl) phosphate (TBOEP) affects growth
RT and development of embryo-larval zebrafish.";
RL Aquat. Toxicol. 191:17-24(2017).
RN [11] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29209278;
RA Safian D., van der Kant H.J.G., Crespo D., Bogerd J., Schulz R.W.;
RT "Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or
RT via Downstream Effectors to Modulate Igf3 Effects on Zebrafish
RT Spermatogenesis.";
RL Front. Endocrinol. 8:328-328(2017).
RN [12] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28515443;
RA Liu C., Dai W., Bai Y., Chi C., Xin Y., He G., Mai K., Duan C.;
RT "Development of a Whole Organism Platform for Phenotype-Based Analysis of
RT IGF1R-PI3K-Akt-Tor Action.";
RL Sci. Rep. 7:1994-1994(2017).
RN [13] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29803886;
RA Dang Y., Wang F., Liu C.;
RT "Real-time PCR array to study the effects of chemicals on the growth
RT hormone/insulin-like growth factors (GH/IGFs) axis of zebrafish
RT embryos/larvae.";
RL Chemosphere 207:365-376(2018).
RN [14] {ECO:0000313|RefSeq:NP_001092224.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30228225; DOI=10.1126/scisignal.aat2231;
RA Liu C., Xin Y., Bai Y., Lewin G., He G., Mai K., Duan C.;
RT "Ca2+ concentration-dependent premature death of igfbp5a-/- fish reveals a
RT critical role of IGF signaling in adaptive epithelial growth. .";
RL Sci. Signal. 11:eaat2231-eaat2231(2018).
RN [15] {ECO:0000313|RefSeq:NP_001092224.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; BX321894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC142807; AAI42808.1; -; mRNA.
DR EMBL; GQ892882; ACZ95800.1; -; mRNA.
DR RefSeq; NP_001092224.1; NM_001098754.1.
DR STRING; 7955.ENSDARP00000057368; -.
DR PaxDb; 7955-ENSDARP00000057368; -.
DR Ensembl; ENSDART00000057369.6; ENSDARP00000057368.5; ENSDARG00000039264.7.
DR GeneID; 795084; -.
DR KEGG; dre:795084; -.
DR AGR; ZFIN:ZDB-GENE-070620-8; -.
DR CTD; 795084; -.
DR ZFIN; ZDB-GENE-070620-8; igfbp5a.
DR eggNOG; ENOG502QUPK; Eukaryota.
DR HOGENOM; CLU_070833_1_1_1; -.
DR OMA; KMYRPLY; -.
DR OrthoDB; 5394492at2759; -.
DR TreeFam; TF331211; -.
DR Proteomes; UP000000437; Alternate scaffold 6.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000039264; Expressed in pharyngeal gill and 10 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001968; F:fibronectin binding; IBA:GO_Central.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IBA:GO_Central.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IBA:GO_Central.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00191; TY; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012213; IGFBP-5.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF4; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 5; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01981; IGFBPFAMILY5.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001092224.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..268
FT /note="Insulin-like growth factor-binding protein 5"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001092224.1"
FT /id="PRO_5035034727"
FT DOMAIN 21..101
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 183..257
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DISULFID 237..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 268 AA; 29966 MW; 702A56BE8929DF11 CRC64;
MLLSLYALVA FVWGLTGISA SFVPCEPCDQ KAMSMCPPVR NGCQVVKEPG CGCCLTCALI
EGQACGVYTG TCGRGLRCLP RIGEEKPLHA LLYGKGVCMN EKLSPYKSMH MPKDQESDED
GMVSEVTEDL LPQAKVPLFQ RDHINSKKAQ AMRKDRKRQQ AKLRTRSHVD YSLFGMEKHQ
SDIGPCRRKL DGIVQRMKDT SRVMALSLYL PNCDKKGFFK RKQCKPSRGR KRGICWCVDK
HGVQMPGTDF NGGNIQCKEV ESHSNNNE
//
