ID A5PMP6_DANRE Unreviewed; 1680 AA.
AC A5PMP6; A0A8M1NDN6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Complement component c3b, tandem duplicate 1 {ECO:0000313|Ensembl:ENSDARP00000118396, ECO:0000313|RefSeq:NP_001093483.1};
GN Name=c3b.1 {ECO:0000313|Ensembl:ENSDARP00000118396,
GN ECO:0000313|RefSeq:NP_001093483.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-2211};
GN Synonyms=si:dkey-21e7.2 {ECO:0000313|RefSeq:NP_001093483.1},
GN wu:fb99g02 {ECO:0000313|RefSeq:NP_001093483.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118396};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000118396, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118396};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000118396}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118396};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001093483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001093483.1};
RX PubMed=24926798;
RA Forn-Cuni G., Reis E.S., Dios S., Posada D., Lambris J.D., Figueras A.,
RA Novoa B.;
RT "The evolution and appearance of C3 duplications in fish originate an
RT exclusive teleost c3 gene form with anti-inflammatory activity.";
RL PLoS ONE 9:e99673-e99673(2014).
RN [4] {ECO:0000313|RefSeq:NP_001093483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001093483.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001093483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001093483.1};
RX PubMed=27821350;
RA Zhang Q.F., Li Y.W., Liu Z.H., Chen Q.L.;
RT "Exposure to mercuric chloride induces developmental damage, oxidative
RT stress and immunotoxicity in zebrafish embryos-larvae.";
RL Aquat. Toxicol. 181:76-85(2016).
RN [6] {ECO:0000313|RefSeq:NP_001093483.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001093483.1};
RX PubMed=30233415;
RA Qin C., Xie Y., Wang Y., Li S., Ran C., He S., Zhou Z.;
RT "Impact of Lactobacillus casei BL23 on the Host Transcriptome, Growth and
RT Disease Resistance in Larval Zebrafish.";
RL Front. Physiol. 9:1245-1245(2018).
RN [7] {ECO:0000313|RefSeq:NP_001093483.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001093483.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; BX649330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX890627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001093483.1; NM_001100013.1.
DR PaxDb; 7955-ENSDARP00000118396; -.
DR PeptideAtlas; A5PMP6; -.
DR Ensembl; ENSDART00000138595; ENSDARP00000118396; ENSDARG00000093068.
DR Ensembl; ENSDART00000138595.3; ENSDARP00000118396.1; ENSDARG00000093068.3.
DR GeneID; 563665; -.
DR KEGG; dre:563665; -.
DR AGR; ZFIN:ZDB-GENE-030131-2211; -.
DR CTD; 563665; -.
DR ZFIN; ZDB-GENE-030131-2211; c3b.1.
DR eggNOG; KOG1366; Eukaryota.
DR HOGENOM; CLU_001634_4_0_1; -.
DR OrthoDB; 4033541at2759; -.
DR PhylomeDB; A5PMP6; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000000437; Alternate scaffold 22.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000093068; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048848; C3_CUB2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF167; COMPLEMENT COMPONENT C3B, TANDEM DUPLICATE 1 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21308; C3_CUB2; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001093483.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1680
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001093483.1"
FT /id="PRO_5035034723"
FT DOMAIN 1527..1678
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 646..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1680 AA; 187604 MW; F380F48CEC9E9668 CRC64;
MLLQLLLWAT LLCQICDGKA FPQRHKRTVW RHMRQIEPVK DPSPSFSLLA PAKIRPGTKQ
NILVEGHNLA QVVEVTVVVY DYPNSQTALS RGSVFLNSDN NYSVLQTLEI NPNLLLPDGK
KKYVKLVAQF SNIYRAEKVM AVSFRSGHIF IQTDKPIYNP GDKVRFRAFV SDLEFRSSER
TISLEIQNPD GIAVHGIGRV KAIDGVFSDI FSLSTVVKYA LRIVQLCLLP AFNVTLTPKT
SHLSLDAEKL EVEITARYLY GAQVKGVAYV LFGIEINGEK KRLTSMKQID DVLNGGSVSL
TMEEIKRAYP DINSLLGSTL YVKASVLTSS GSDLVEAEKS GIKIVKSPYM LTIKDTPKYY
KPGLPLAMTV IVSNHDGSPT PNIPVKVTFL ESPISVHSGT INIHINMPKT HILYGNSQIL
KVETVDPSLK PEQQAIQEVY VKPYSTFSGH DNFLHVSVGA SRVVVGGSVS VQMYIKSSLP
NHRALVEHLT YIVLNKGKII QAGRVNVKGQ DVTSVHLLIT TEMLPAFRFV AYYVLPWQHR
AEVVADSVFV DVEDRCVGSL NVGPVDGEIV SSYSPGSSFK FQVKGDVGAK VSLVAVDNAI
FLLSKNRLTQ KKVWEVVDQA DMGCTAGGGK DNMGVFSDAG LMFHSSTGGS TDSKEDCSSK
TKRRRRSAAK LQLRDQLEKA YSDELLQRCC VDGMKEIPMP YSCYRRSLYI TEDWSFFFVR
DRVLQSMPKL HAEANVVGVR QDSYREVVVE EEEEAASVFE EDDLSDLEDI YVRSKFFESW
LWTDIRLPST AKSDGLAVFP VDTVLPDSIT QWGFLAVSAS PEKGVCVAEP YNVRVWKPFF
IDLRLPHSVS RNEQVEIKAV IHNYKNSTLE VRSTPSVVMV ILEKTEDMCS VAYTGQHRQQ
VTVAAGSSKL ITYTIIPLKT GELPLQVTAV AASFMGQDAV KKNLRVVVEG IQTLKVRSFV
LNPSEKGGSA GQQLIQVKKM QLDAVVPKSV PETFVNVRGD LLADSIDNSI KEDSLAALIR
MPGGCVEQNL ARITLPLIAA HYLDRSADWE IVGISRREEA IKYIQRGYEN QLNYKKSDDS
YPPYANEGTS TWITAYVVKV FSMAHSFINV NEKHLCGPLL YLLKNKQGYD GTFQEDNPVY
DTSMTGAMRG SEYKASLTAF VLIALAEAQD KVTCQDQEVN IRDKSRQAAG YLTEHFSRLT
RPYTAAIACY ALAVSNNACV KSMLLKFASP DHSHWPDSNN YFFTLEATGY ALLALIKSGH
MEEAEAPFRW LNEHRGIGGG YGSTQSTMVV LQALSEYLVK RPPPSDLNLL VQLSVPGRSD
VRWTFNPNLA YVARSSRVPL DQEFSVAASG NGKGVLEVVT VYHQLPDVYE NSTCNGFQLD
VSIAETNEKT SSDVEKSFRL NVNVRALEER QVRMVILDIG LPTGFEPENS DLELLTNSVD
RYINNFQVVD NLSDRGSLII HLFKVSNKEA EMISFRLNQK FKVGLLQPST VKVYQYYNKD
KSCSRFYSPP EDKQQLDQIC EGDVCRCSQG DCCVMKEDFA FFGKEQRNAA VCNGLHHAYR
VKLISISQSH YYQYEMEIVQ VIKEGTEEGL NEKERRMFLS HASCRTRLNL KEGQEYLVIG
PITDVWNAGS TVSNKYVYTL GKETWVERWP DESECGSTLQ KKCDELKSFA KKLIEDGCQA
//
