ID A5UJB6_METS3 Unreviewed; 259 AA.
AC A5UJB6;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Pyrroline-5-carboxylate reductase (NADP oxidoreductase, coenzyme F420-dependent), ProC {ECO:0000313|EMBL:ABQ86294.1};
DE EC=1.5.1.2 {ECO:0000313|EMBL:ABQ86294.1};
GN OrderedLocusNames=Msm_0089 {ECO:0000313|EMBL:ABQ86294.1};
OS Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=420247 {ECO:0000313|EMBL:ABQ86294.1, ECO:0000313|Proteomes:UP000001992};
RN [1] {ECO:0000313|EMBL:ABQ86294.1, ECO:0000313|Proteomes:UP000001992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35061 / DSM 861 / OCM 144 / PS
RC {ECO:0000313|Proteomes:UP000001992};
RX PubMed=17563350; DOI=10.1073/pnas.0704189104;
RA Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B.,
RA Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.;
RT "Genomic and metabolic adaptations of Methanobrevibacter smithii to the
RT human gut.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
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DR EMBL; CP000678; ABQ86294.1; -; Genomic_DNA.
DR RefSeq; WP_011953675.1; NZ_CP117965.1.
DR AlphaFoldDB; A5UJB6; -.
DR STRING; 420247.Msm_0089; -.
DR EnsemblBacteria; ABQ86294; ABQ86294; Msm_0089.
DR GeneID; 78816713; -.
DR KEGG; msi:Msm_0089; -.
DR PATRIC; fig|420247.28.peg.92; -.
DR eggNOG; arCOG00455; Archaea.
DR HOGENOM; CLU_042344_2_0_2; -.
DR BioCyc; MSMI420247:GHWZ-89-MONOMER; -.
DR Proteomes; UP000001992; Chromosome.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.3730.10; ProC C-terminal domain-like; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR029036; P5CR_dimer.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR PANTHER; PTHR11645:SF53; PYRROLINE-5-CARBOXYLATE REDUCTASE 3; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF14748; P5CR_dimer; 1.
DR PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00521; P5CR; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|PIRSR:PIRSR000193-1};
KW Oxidoreductase {ECO:0000313|EMBL:ABQ86294.1}.
FT DOMAIN 3..97
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
FT DOMAIN 164..255
FT /note="Pyrroline-5-carboxylate reductase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF14748"
FT BINDING 56
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
SQ SEQUENCE 259 AA; 28772 MW; C89A11F8A75DDB51 CRC64;
MNLGIIGYGN IGELLSQNII SHDFCNLNKL YIANRTLSKI NHLKDIDPRI SITDDNIEVA
KNCEKIIISV KTPDLANVLD PLKPHITKNT QIIHTCAGTD LEFKDCGLSC VIPTISSTYD
EDNPKKGVSI IMHDENVSGE NREFVEKLFS KFSQIKVVDS PMDLEIATIA ASCMPAFIAL
GLDLFAGELE EKCNLSKEET FKILAETLNS TAYILKEDIY SPDELINKVA TKNGITQKGL
DVLDKDLPDI YKRLISKLL
//
