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Database: UniProt
Entry: A5UU13_ROSS1
LinkDB: A5UU13_ROSS1
Original site: A5UU13_ROSS1 
ID   A5UU13_ROSS1            Unreviewed;       459 AA.
AC   A5UU13;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   05-JUN-2019, entry version 74.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=RoseRS_1726 {ECO:0000313|EMBL:ABQ90116.1};
OS   Roseiflexus sp. (strain RS-1).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Roseiflexineae;
OC   Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=357808 {ECO:0000313|EMBL:ABQ90116.1, ECO:0000313|Proteomes:UP000006554};
RN   [1] {ECO:0000313|Proteomes:UP000006554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS-1 {ECO:0000313|Proteomes:UP000006554};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Roseiflexus sp. RS-1.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP000686; ABQ90116.1; -; Genomic_DNA.
DR   RefSeq; WP_011956463.1; NC_009523.1.
DR   STRING; 357808.RoseRS_1726; -.
DR   EnsemblBacteria; ABQ90116; ABQ90116; RoseRS_1726.
DR   KEGG; rrs:RoseRS_1726; -.
DR   eggNOG; ENOG4105C7S; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   HOGENOM; HOG000281566; -.
DR   KO; K00627; -.
DR   OMA; TMEFESF; -.
DR   OrthoDB; 1626282at2; -.
DR   BioCyc; RSP357808:G1G8U-1804-MONOMER; -.
DR   Proteomes; UP000006554; Chromosome.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ABQ90116.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006554};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006554};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ABQ90116.1}.
FT   DOMAIN        1     76       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      124    161       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION       90    121       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A5UU13}.
FT   REGION      167    221       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A5UU13}.
FT   COMPBIAS     90    114       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A5UU13}.
FT   COMPBIAS    170    221       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A5UU13}.
SQ   SEQUENCE   459 AA;  47547 MW;  3C859035BEE6FB0E CRC64;
     MPDITMPKMG FDMQEGTIVR WLKKPGDAVR RGEPIAEIET DKVTIEIEAF ESGTLTEIVV
     QEGQSAPVNA VIARLDGGNG SQAPVPVAAA PAVPPPAEVS PPPAPLPETP APLAEPPADI
     GDIRASPLAR RLAREYGIDL RQVRGSGPAG RIVKEDIEAY LSARGGAPAP TPVSAPPPAP
     AAVSAPPPAP AAVSAPPPAP AAVSAPPPAP AAVSAPPPAP AAVSVAQPTA GAVVPLSNMR
     KTISRRMIQS WQQFPHIFVS IEVDMGAALA LRAQANAGRP REDQISVNDM VVKACAVALL
     AFPNLNASYS DDGIILHPTV NIAIAVALES GLMAPVVANC QDRSLGSIAR ETKRIVALAR
     EGKITPDLLQ GGTFTVSNLG MYGIPEFTSI ITPPQAASLA VGAIRRTPAF KDDSDEVVAK
     HLMMLTLSAD HRVTDGAEVA RFLNDVKRLL EQPLALLVG
//
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