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Database: UniProt
Entry: A5VHV6_LACRD
LinkDB: A5VHV6_LACRD
Original site: A5VHV6_LACRD 
ID   A5VHV6_LACRD            Unreviewed;       450 AA.
AC   A5VHV6;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   05-DEC-2018, entry version 65.
DE   SubName: Full=Permease for cytosine/purines, uracil, thiamine, allantoin {ECO:0000313|EMBL:ABQ82430.1};
GN   OrderedLocusNames=Lreu_0158 {ECO:0000313|EMBL:ABQ82430.1};
OS   Lactobacillus reuteri (strain DSM 20016).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=557436 {ECO:0000313|EMBL:ABQ82430.1, ECO:0000313|Proteomes:UP000001991};
RN   [1] {ECO:0000313|Proteomes:UP000001991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20016 {ECO:0000313|Proteomes:UP000001991};
RX   PubMed=21379339; DOI=10.1371/journal.pgen.1001314;
RA   Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M.,
RA   Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M.,
RA   Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L.,
RA   Ivanova N., Kyrpides N.C., Walter J.;
RT   "The evolution of host specialization in the vertebrate gut symbiont
RT   Lactobacillus reuteri.";
RL   PLoS Genet. 7:E1001314-E1001314(2011).
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39)
CC       family. {ECO:0000256|PIRNR:PIRNR002744}.
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DR   EMBL; CP000705; ABQ82430.1; -; Genomic_DNA.
DR   RefSeq; WP_003667117.1; NZ_AZDD01000005.1.
DR   ProteinModelPortal; A5VHV6; -.
DR   EnsemblBacteria; ABQ82430; ABQ82430; Lreu_0158.
DR   GeneID; 5189552; -.
DR   KEGG; lre:Lreu_0158; -.
DR   PATRIC; fig|557436.17.peg.1496; -.
DR   HOGENOM; HOG000288688; -.
DR   OMA; EKHTIGY; -.
DR   BioCyc; LREU557436:G1G8Z-164-MONOMER; -.
DR   Proteomes; UP000001991; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.4160.10; -; 1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   InterPro; IPR038271; Pur-cyt_permease_sf.
DR   PANTHER; PTHR31806; PTHR31806; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   PIRSF; PIRSF002744; Pur-cyt_permease; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001991};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002744, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001991};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR002744}.
FT   TRANSMEM     21     45       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     51     71       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     98    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    201    222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    234    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    320    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    348    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    412       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    442       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   450 AA;  49293 MW;  3BF8ED1BBF712AA8 CRC64;
     MDNEFVKVPE KDKTLSPGKL FYNWFAANIG IMGFVYGAII VSYHLSFWQS VTAALIGALT
     FAIPGWVAMI GQREGVTTFK MSRATFGTHG NKIPNFMAWL NMVGWLAVNV ITGTLLFSAM
     LKTIHVPQTG FTKFICLVVF AGLVFLSGIF KEDTLAKIQT WLSWIFGGLT LVMLIMFLMN
     ANWGEAFAMK PGSWVTGWLP AVAFIAAGSS ISWSMAAADW GAYVHPNTKP SATFWNTTLG
     AATPLFILMA GGVLLSTISP SLASASDPYQ VMYGVIPGWF GFLYFLVAAG GIIPQCLVSF
     RSARINLSTI GIEVSQKRSL ILHAVIIILI SIYVLFISGD FLSNFELFLN FLGICLASWV
     AIFLVDSVIY RKNGYDVKLM EPNSSVHYNW PGIISWIIAT IFGFLFTSNA AYRGPFAHGI
     FENNSSLAVF VSGIAAIIVM FIKSSDKQED
//
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