ID A5ZAT8_9FIRM Unreviewed; 1220 AA.
AC A5ZAT8;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=addA {ECO:0000313|EMBL:EDM50189.1};
GN ORFNames=EUBVEN_02840 {ECO:0000313|EMBL:EDM50189.1};
OS Eubacterium ventriosum ATCC 27560.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=411463 {ECO:0000313|EMBL:EDM50189.1, ECO:0000313|Proteomes:UP000006000};
RN [1] {ECO:0000313|EMBL:EDM50189.1, ECO:0000313|Proteomes:UP000006000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27560 {ECO:0000313|EMBL:EDM50189.1,
RC ECO:0000313|Proteomes:UP000006000};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDM50189.1, ECO:0000313|Proteomes:UP000006000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27560 {ECO:0000313|EMBL:EDM50189.1,
RC ECO:0000313|Proteomes:UP000006000};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Eubacterium ventriosum (ATCC 27560).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM50189.1}.
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DR EMBL; AAVL02000038; EDM50189.1; -; Genomic_DNA.
DR RefSeq; WP_005360829.1; NZ_DS264270.1.
DR AlphaFoldDB; A5ZAT8; -.
DR STRING; 411463.EUBVEN_02840; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_3_1_9; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000006000; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..468
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 484..776
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1220 AA; 139363 MW; 64A07B05E2853806 CRC64;
MKWTDKQQKV IDTRDRNILV SAAAGSGKTA VLVERIIKMI TDEENPTDVN QLLVVTFTRA
AASEMKERIR EALEKMEEDN PNDLNVQKQL SLIHNANIST IDSFCARVVK DNFDKIDLDP
NFRIADENEI EMLQSDIVEE MLEEYYLAAD DEFMELAEKY STGKTSDSIG ELILRMYKFA
SGQIEPEKWI KEAISVYDVS SKEEMEQSKW MQGYLELQKN RLEGILSQLN IALTISESED
GPKCAKALTP IIDKLQEITE SRTYSAMQSE LQNIPSTRVS GKKDCNERKK EQVKAIKNDA
TKAIKDLTTK QFNLTLNQVF ESICETKSSV EYIGKLTLEF MKRLKEQKEE KGIMDFNDQA
FFALHILNEY DKDGNLVPSE TAKNMATQFK EIMIDEYQDS NIIQEAILSA ITKGFGINNM
FMVGDVKQSI YRFRNAEPKL FLEKYNSFSD DPSADSVKIV LDKNFRSRRE VIESVNFLFD
FVMHEEVGGI DYKNGNGLVL GADYDEPPAG QDNLTEFVMV EGGDKSDEAA YVARKIKEIT
NPETGLKITE KGKDMRPVRY GDIVILLRSM KDNSDIYREQ LENNGIPVFA ESKTGYYKTM
EVMTITNMLS IIDNPRQDIP LAAVLTSPMF GFDSNQLAII KTENVCESFY DCVEQYSLSG
SDVELRTRLT EFLNTLTKFR NMVPYTTVYD LINTLLDETG YAFYIRSMPG GKKRLLNIQA
LKEKAVAYDE TSYKGLFNFL RYIEKIQYLA KDDGEASTVN ENDNIVRIMS IHKSKGLQFP
VVFLCNTNGT SKNEANQLVS GADGNIGIDC INNKLKTKQT PLLKTYIRMS NKEEDVAETL
RILYVALTRA KEKLYITGLV KNAEKQIGEF ESQIYDNSEL MLYNDVIGAK TIMELIGKTI
GRNKAFDCVR TDKDATECGN PLYDKDSFIK VKVEEQPDVI LGLAAEDITD SIKKETMLME
MKQLANKENT SIEKLFQRFQ FQYPYIEDIT LHSKASVTEI KKQSQGMEQE EEQDAFQAFG
EEVELPEIIP DFEKEDIDEP QYLTGAMRGT AYHRIFELLD MELEEYNQET VKKMIDGFVD
AGLIDRMGAA SVMRKDIIDF TKSDLFRRMK KAYANNQLYR EQHFLMGVPA CEINSNTTSK
ETMIIQGIID LCFVENDKYV IVDYKTDKVD TMEELVERYH VQLECYKLAI EQILGSEPGV
NKVSEMIIYS VHLGQQITIK
//